Product image of Lipanthyl Micronisé (Fenofibrate) supplied by GNH India

Lipanthyl Micronisé

Active Ingredient:
Fenofibrate
Origin:
EU

Lipanthyl Micronisé (Fenofibrate)

Fenofibrate, the active ingredient in Lipanthyl Micronisé, is a fibric acid derivative presented as a micronised oral tablet for oral use. It is employed to lower elevated triglyceride levels and to improve lipid profiles in patients with dyslipidaemia, helping reduce cardiovascular risk and is indicated for the management of hypertriglyceridaemia and mixed dyslipidaemia.

GNH India supplies Lipanthyl Micronisé as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and procurement teams worldwide across multiple continents.

Manufacturer / TM Owner

Viatris Medical

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Indications & Clinical Uses

  • Lipanthyl Micronisé (fenofibrate) acts on lipid metabolism pathways to modify triglyceride‑rich lipoproteins and is used in several dyslipidaemia conditions, including primary and secondary forms.
  • Hypertriglyceridaemia: lowers serum triglyceride concentrations, reducing the risk of pancreatitis and supporting overall lipid balance.
  • Mixed dyslipidaemia: decreases triglycerides and modestly reduces LDL‑cholesterol while raising HDL‑cholesterol, improving the atherogenic profile.
  • Secondary prevention of cardiovascular disease associated with dyslipidaemia: contributes to risk reduction when combined with statin therapy and lifestyle measures.

How It Works

  • Fenofibrate activates peroxisome proliferator‑activated receptor‑alpha (PPARα) in hepatic and peripheral tissues. Activation of PPARα up‑regulates genes involved in fatty‑acid β‑oxidation, enhances lipoprotein lipase activity, and reduces synthesis of triglyceride‑rich very‑low‑density lipoproteins. The resulting metabolic shift accelerates clearance of triglyceride‑rich particles and modestly raises high‑density lipoprotein levels, contributing to an improved lipid profile. These actions collectively lower plasma triglyceride concentrations and favorably modify other lipid parameters.

Side Effects

Fenofibrate may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort: nausea, abdominal pain or dyspepsia
  • Headache: mild to moderate intensity
  • Dizziness: transient episodes
  • Elevated liver enzymes: mild increases in ALT or AST

Serious or Rare Side Effects

  • Rhabdomyolysis: muscle breakdown with potential renal failure
  • Severe liver injury: hepatitis or hepatic failure
  • Allergic reactions: rash, pruritus or angioedema

Precautions & Warnings

When prescribing fenofibrate, clinicians should consider several precautionary measures to ensure patient safety.

  • Monitor liver function: obtain baseline transaminases and repeat periodically.
  • Assess renal function: adjust use in patients with severe impairment.
  • Review concomitant medications: avoid or monitor use with statins and gemfibrozil.
  • Avoid in active gallbladder disease: fenofibrate can promote gallstone formation.
  • Pregnancy and lactation: use only if potential benefit justifies potential risk.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Fenofibrate can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Gemfibrozil: combined use markedly increases risk of myopathy and rhabdomyolysis.
  • High‑dose statins (e.g., simvastatin >40 mg): additive risk of muscle toxicity.
  • Cyclosporine: may raise fenofibrate plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Warfarin: fenofibrate may potentiate anticoagulant effect, requiring INR monitoring.
  • Thiazide diuretics: can cause modest increases in serum creatinine.
  • Oral contraceptives: may attenuate triglyceride‑lowering response.

Frequently Asked Questions

Lipanthyl Micronisé contains fenofibrate, which is prescribed to lower high triglyceride levels, improve mixed dyslipidaemia, and aid in the secondary prevention of cardiovascular disease linked to abnormal lipid profiles. It is used in patients whose lipid abnormalities persist despite diet, exercise, or other lipid‑lowering therapies.

Fenofibrate activates the nuclear receptor PPARα, which regulates genes involved in fatty‑acid oxidation and lipoprotein metabolism. By enhancing the breakdown of triglycerides and increasing the activity of lipoprotein lipase, it promotes clearance of triglyceride‑rich particles and modestly raises HDL‑cholesterol, leading to an overall better lipid profile.

The appropriate dose of Lipanthyl Micronisé is determined by the prescribing healthcare professional based on the individual’s clinical condition, laboratory results, and concomitant therapies. Dosage may be adjusted over time, and patients should follow the prescriber’s instructions without altering the regimen on their own.

Safety data for fenofibrate in pregnancy and lactation are limited. It should be used only if the potential therapeutic benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the risks and benefits with their healthcare provider.

To request Lipanthyl Micronisé, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Fenofibrate belongs to the fibric acid class, which primarily lowers triglycerides and modestly raises HDL‑cholesterol. Statins, the most common alternative, mainly reduce LDL‑cholesterol and have a broader evidence base for cardiovascular event reduction. In patients with severe hypertriglyceridaemia, fenofibrate may be preferred, while statins are often first‑line for LDL‑cholesterol management.

Store Lipanthyl Micronisé at ambient temperature, preferably below 25 °C. Keep the tablets in the original blister pack or container, protect them from moisture, heat, and direct light. Do not refrigerate or freeze the product, and ensure it is kept out of reach of children.

Lipanthyl Micronisé is taken orally, usually once daily with a meal to enhance absorption. The tablet should be swallowed whole with water and not crushed or chewed unless otherwise directed by a healthcare professional. Consistency with food intake helps maintain stable drug levels.

The most serious adverse events linked to fenofibrate include rhabdomyolysis (muscle breakdown that can lead to kidney failure), severe liver injury such as hepatitis or hepatic failure, and rare hypersensitivity reactions like angioedema. Patients should be monitored for muscle pain, unexplained fatigue, jaundice, or signs of an allergic reaction and report them promptly.

Fenofibrate is contraindicated in individuals with active liver disease, severe renal impairment, known gallbladder disease, or a history of hypersensitivity to fenofibrate or other fibric acid derivatives. It should also be avoided in patients taking gemfibrozil or other medications that significantly increase the risk of myopathy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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