Product image of Neoproct Yhdistelmäpakkaus (Fluocortolone Pivalate, Anhydrous Lidocaine Hydrochloride) supplied by GNH India

Neoproct Yhdistelmäpakkaus

Active Ingredient:
Fluocortolone Pivalate, Anhydrous Lidocaine Hydrochloride
Origin:
EU

Neoproct Yhdistelmäpakkaus (Fluocortolone Pivalate, Anhydrous Lidocaine Hydrochloride)

Fluocortolone pivalate, the active ingredient in Neoproct Yhdistelmäpakkaus, is a corticosteroid presented as a rectal formulation for local use. Combined with lidocaine hydrochloride, it is intended to reduce inflammation and relieve pain in conditions such as proctitis, hemorrhoids and anal fissures.

GNH India supplies Neoproct Yhdistelmäpakkaus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Karo Pharma Ab

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Indications & Clinical Uses

  • Neoproct Yhdistelmäpakkaus is used to manage inflammatory and painful conditions of the rectal area.
  • Rectal inflammation (proctitis): reduces swelling and promotes healing.
  • Hemorrhoids: alleviates swelling and discomfort.
  • Anal fissures: decreases inflammation and eases pain during bowel movements.
  • General rectal pain and discomfort: provides local anaesthesia and anti‑inflammatory effect.

How It Works

  • Fluocortolone pivalate binds to intracellular glucocorticoid receptors, modulating gene transcription to suppress pro‑inflammatory cytokines, reduce leukocyte migration, and stabilize cellular membranes. Lidocaine hydrochloride blocks voltage‑gated sodium channels in peripheral nerves, preventing depolarisation and producing a reversible loss of sensation in the treated rectal tissue.

Side Effects

Local rectal administration of Neoproct Yhdistelmäpakkaus may be associated with a range of adverse reactions.

Common Side Effects

  • Mild burning or stinging at the application site
  • Transient itching
  • Minor rectal irritation
  • Temporary increase in bowel movements
  • Mild headache

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis)
  • Rectal ulceration or tissue necrosis
  • Systemic corticosteroid effects such as adrenal suppression
  • Persistent numbness or loss of sensation
  • Infection at the application site

Precautions & Warnings

  • Before using Neoproct Yhdistelmäpakkaus, consider the following precautions to ensure safe and effective therapy.
  • Pregnancy: consult a healthcare professional before use, as safety data are limited.
  • Breastfeeding: discuss potential risks with a physician.
  • Existing infections: avoid use on infected or ulcerated tissue.
  • Concurrent corticosteroid therapy: monitor for additive systemic effects.
  • Allergy to lidocaine or corticosteroids: contraindicated.
  • Store below 25°C: keep in the original pack, protect from moisture and heat.

Avoid Interactions

Neoproct Yhdistelmäpakkaus can interact with other medicines; the following interactions are recognised.

Major Interactions (Avoid)

  • Systemic corticosteroids: may increase risk of systemic glucocorticoid effects.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): can raise local corticosteroid levels.
  • Other local anesthetics: may cause cumulative nerve toxicity.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (e.g., warfarin): corticosteroid may enhance bleeding risk.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): combined irritation of rectal mucosa.
  • Immunosuppressants: may reduce local immune response.

Frequently Asked Questions

Neoproct Yhdistelmäpakkaus is a rectally administered combination of fluocortolone pivalate and lidocaine hydrochloride. It is indicated for the treatment of rectal inflammation (proctitis), hemorrhoids, anal fissures, and general pain or discomfort in the anal region by providing anti‑inflammatory and local anaesthetic effects.

Fluocortolone pivalate is a synthetic glucocorticoid that binds to intracellular glucocorticoid receptors. This interaction alters gene transcription, leading to reduced production of inflammatory mediators, decreased leukocyte infiltration, and stabilization of cell membranes, thereby diminishing swelling and pain in the treated area.

The appropriate dose and frequency of Neoproct Yhdistelmäpakkaus are determined by the prescribing healthcare professional based on the severity of the condition, patient age, and response to therapy. Patients should follow the specific instructions provided by their prescriber and not alter the regimen without medical advice.

Safety data for fluocortolone pivalate and lidocaine hydrochloride in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their physician before using this product.

To request Neoproct Yhdistelmäpakkaus, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Neoproct Yhdistelmäpakkaus combines a potent corticosteroid (fluocortolone pivalate) with a local anaesthetic (lidocaine), offering both anti‑inflammatory and pain‑relieving actions in a single formulation. Compared with products that contain only a corticosteroid such as hydrocortisone, Neoproct may provide faster symptom relief due to the added anaesthetic effect, though the choice depends on clinical judgment.

Store Neoproct Yhdistelmäpakkaus below 25 °C in its original packaging, protecting it from moisture, direct sunlight, and excessive heat. Keep the product out of reach of children and avoid exposing it to temperatures that could compromise its stability.

Neoproct Yhdistelmäpakkaus is applied rectally, typically using a supplied applicator or a clean fingertip. The prescribed amount is gently inserted into the rectal canal, ensuring even distribution over the affected mucosa. Patients should follow the exact administration instructions given by their healthcare provider.

Serious adverse events, although rare, can include severe allergic reactions (anaphylaxis), rectal ulceration or tissue necrosis, systemic corticosteroid effects such as adrenal suppression, persistent numbness, and secondary infections at the application site. Any of these symptoms require immediate medical attention.

Neoproct Yhdistelmäpakkaus should be avoided in individuals with known hypersensitivity to fluocortolone pivalate, lidocaine, or any excipients in the formulation. It is also contraindicated on severely infected, ulcerated, or necrotic rectal tissue, and in patients for whom systemic corticosteroid exposure is contraindicated without close medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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