Inovox Ultra Smak Miętowy (Flurbiprofen)

Flurbiprofen acts on inflammatory pathways to manage pain and swelling in several musculoskeletal conditions.

• Rheumatoid arthritis: reduces joint pain, swelling and stiffness.
• Osteoarthritis: alleviates chronic joint discomfort and improves mobility.
• Musculoskeletal pain: provides short‑term relief of acute injuries, strains and sprains.
• Post‑operative pain: helps control pain after surgical procedures.
• Ankylosing spondylitis: diminishes spinal inflammation and pain.

• Flurbiprofen reversibly inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, decreasing the conversion of arachidonic acid to prostaglandins. The reduced prostaglandin synthesis leads to diminished inflammation, pain signaling, and fever responses at the site of tissue injury.

Flurbiprofen may cause a range of adverse reactions, from mild to severe.

Common Side Effects

• Gastrointestinal upset: nausea, dyspepsia or abdominal pain.
• Headache: mild to moderate intensity.
• Dizziness or vertigo.
• Skin rash or pruritus.
• Elevated liver enzymes.
• Mild renal function changes.

Serious or Rare Side Effects

• Gastrointestinal bleeding or ulcer perforation.
• Severe allergic reactions: anaphylaxis, angioedema.
• Renal failure or acute kidney injury.
• Cardiovascular events: myocardial infarction or stroke.
• Hepatotoxicity with jaundice.
• Blood dyscrasias such as agranulocytosis.

When prescribing flurbiprofen, consider patient‑specific risk factors and monitor appropriately.

• Assess gastrointestinal risk: avoid in patients with active ulcers or a history of GI bleeding.
• Monitor renal function: caution in those with chronic kidney disease or dehydration.
• Avoid in known hypersensitivity to NSAIDs or aspirin.
• Use the lowest effective dose for the shortest duration needed.
• Caution with concurrent anticoagulants or antiplatelet agents.
• Store at ambient temperature: keep in the original pack, protect from moisture.

Flurbiprofen can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased bleeding risk.
• Other NSAIDs or aspirin: additive gastrointestinal toxicity.
• Corticosteroids: heightened ulcer risk.
• Selective serotonin reuptake inhibitors (SSRIs): potential for bleeding.
• Lithium: elevated lithium levels.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: possible reduction in renal function.
• Diuretics: risk of renal impairment.
• Methotrexate: decreased clearance, leading to toxicity.
• Antihypertensives: may blunt blood pressure control.
• Oral hypoglycemics: potential alteration of glucose control.