Meboflur Cseresznye És Menta Ízű (Flurbiprofen)

Flurbiprofen is an NSAID that reduces inflammation and pain by inhibiting cyclooxygenase enzymes.

• Mild to moderate pain: provides analgesic relief for general discomfort.
• Dental pain: alleviates pain associated with dental procedures or conditions.
• Sore throat: reduces pain and inflammation in the throat.

• Flurbiprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis diminishes inflammation, lowers peripheral sensitisation of nociceptors, and produces analgesic and antipyretic actions at the site of injury or irritation.

Common Side Effects

• Taste alteration: a mild, temporary change in oral flavour perception.
• Nausea: occasional mild stomach upset.
• Oral irritation: transient burning or tingling in the mouth.
• Dizziness: brief sensation of light‑headedness.
• Headache: mild to moderate intensity.
• Mild gastrointestinal discomfort: occasional stomach ache.

Serious or Rare Side Effects

• Severe allergic reactions: rash, swelling, or anaphylaxis.
• Gastrointestinal bleeding or ulceration: signs include black stools or vomiting blood.
• Renal impairment: reduced kidney function, especially with prolonged use.
• Hepatic dysfunction: abnormal liver enzymes or jaundice.
• Stevens‑Johnson syndrome: severe skin reactions.
• Cardiovascular events: increased risk of heart attack or stroke in susceptible individuals.

Before using Flurbiprofen, consider the following safety measures.

• Assess renal function: adjust use in patients with existing kidney disease.
• Monitor gastrointestinal health: avoid in active ulcer disease or recent GI bleeding.
• Avoid concurrent anticoagulants: increased risk of bleeding when combined with warfarin or DOACs.
• Use with caution in asthma: NSAIDs may exacerbate bronchospasm.
• Store at ambient temperature: keep in the original pack, protect from moisture and heat.

Flurbiprofen may interact with several medicines; review patient medication lists carefully.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin, DOACs): heightened bleeding risk.
• Other NSAIDs or COX‑2 inhibitors: additive toxicity and GI risk.
• Corticosteroids: increased likelihood of gastrointestinal ulceration.

Moderate Interactions (Monitor Closely)

• SSRIs (e.g., sertraline, fluoxetine): may increase bleeding tendency.
• Methotrexate: reduced clearance leading to toxicity.