Orofar Intensiv Portocale Fără Zahăr (Flurbiprofen)

Flurbiprofen is an NSAID that acts on inflammatory pathways to provide analgesic and anti‑inflammatory effects.

• Rheumatoid arthritis: helps reduce joint pain, swelling and stiffness.
• Osteoarthritis: alleviates pain and improves joint function.
• Acute musculoskeletal pain: provides short‑term relief of pain and inflammation following injury or surgery.

• Flurbiprofen inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, decreasing the synthesis of prostaglandins that mediate inflammation, pain and fever. This reduction in prostaglandin levels leads to diminished inflammatory responses and analgesia in peripheral tissues.

Flurbiprofen may cause a range of adverse reactions, most of which are dose‑dependent and reversible.

Common Side Effects

• Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain.
• Headache: mild to moderate intensity.
• Dizziness: transient episodes of light‑headedness.
• Skin rash: mild erythema or itching.
• Elevated liver enzymes: mild, asymptomatic increases in laboratory tests.

Serious or Rare Side Effects

• Gastrointestinal ulceration or bleeding: may present with black stools or vomiting blood.
• Renal impairment: sudden decrease in urine output or swelling.
• Severe hypersensitivity reactions: anaphylaxis, angioedema or bronchospasm.
• Cardiovascular events: increased risk of heart attack or stroke.
• Liver injury: jaundice or marked elevation of liver enzymes.
• Blood dyscrasias: thrombocytopenia or leukopenia.

When using Flurbiprofen, consider the following safety measures:

• Assess renal function: evaluate kidney health before initiating therapy.
• Monitor hepatic function: check liver enzymes periodically during treatment.
• Evaluate cardiovascular risk: use cautiously in patients with a history of heart disease.
• Avoid concurrent NSAIDs: reduce risk of gastrointestinal complications.
• Use gastro‑protective agents: consider proton‑pump inhibitors in high‑risk individuals.
• Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Flurbiprofen can interact with several medication classes, altering efficacy or safety.

Major Interactions (Avoid)

• Anticoagulants: increased risk of bleeding.
• Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding tendency.
• Angiotensin‑converting enzyme inhibitors (ACE‑I): may reduce renal perfusion.
• Diuretics: potential for reduced kidney function.\nModerate Interaction (Monitor Closely):
• Corticoses (c)