Product image of Fresofol 1% LCT (Propofol IP) 10mg Ampoules supplied by GNH India

Fresofol 1% LCT

Active Ingredient:
Propofol IP
Form:
Ampoules
Brand:
Fresofol 1% MCT/LCT
Origin:
Austria

Fresofol 1% LCT (Propofol IP Ampoules) 10mg

Propofol IP, the active ingredient in Fresofol 1% LCT, is a sedative-hypnotic presented as a 10mg/ampoule for intravenous use. It is used for the induction and maintenance of general anesthesia and procedural sedation in adults and children. GNH India supplies Fresofol 1% LCT as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals and clinics worldwide.

Fresofol 1% LCT is a brand of Propofol IP, a widely used anesthetic agent known for its rapid onset and short duration of action. It is formulated as an emulsion for intravenous administration, ensuring quick and effective sedation.

Strength

10mg

Pack Size

5s

Storage

15-25°

Manufacturer / TM Owner

Fresenius Kabi Austria GmbH

1
Pack/s
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Indications & Clinical Uses

Fresofol 1% LCT is used for the induction and maintenance of general anesthesia and procedural sedation. It acts on the central nervous system to produce sedation and anesthesia.

  • Induction of general anesthesia: Achieves rapid loss of consciousness for surgical procedures.
  • Maintenance of general anesthesia: Sustains unconsciousness during surgery.
  • Procedural sedation: Provides sedation for diagnostic and therapeutic procedures.

How It Works

  • Propofol IP works by positively modulating the GABA_A receptor, which enhances the inhibitory effects of the neurotransmitter GABA. This leads to central nervous system depression, resulting in sedation and anesthesia. The rapid onset and short duration of action make it suitable for both induction and maintenance of anesthesia.

Side Effects

Fresofol 1% LCT may cause various side effects, ranging from common to serious.

Common Side Effects

  • Pain at the injection site: Localized discomfort or irritation.
  • Hypotension: Lowered blood pressure.
  • Respiratory depression: Slowed or shallow breathing.
  • Nausea and vomiting: Gastrointestinal disturbances.
  • Dizziness: Lightheadedness or vertigo.
  • Headache: Mild to moderate headache.

Serious or Rare Side Effects

  • Anaphylaxis: Severe allergic reaction requiring immediate medical attention.
  • Apnea: Temporary cessation of breathing.
  • Bradycardia: Abnormally slow heart rate.
  • Seizures: Uncontrolled electrical activity in the brain.

Precautions & Warnings

Fresofol 1% LCT should be used with caution and under medical supervision. Certain precautions and warnings should be observed.

  • Administration: Should be administered by trained healthcare professionals in a monitored setting.
  • Hypersensitivity: Avoid use in patients with known hypersensitivity to Propofol IP or any of its components.
  • Cardiovascular conditions: Use with caution in patients with cardiovascular diseases.
  • Respiratory conditions: Monitor closely in patients with respiratory disorders.
  • Pregnancy: Use during pregnancy only if clearly needed, as safety in pregnant women has not been established.
  • Store at 2-8°C: Keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Fresofol 1% LCT may interact with other medications, potentially altering its effects or increasing the risk of side effects.

Major Interactions (Avoid)

  • Opioids: Concurrent use may enhance respiratory depression.
  • Benzodiazepines: Increased risk of profound sedation and respiratory depression.
  • Other anesthetics: May potentiate the sedative effects of Propofol IP.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: May exacerbate hypotension.
  • Antidepressants: Potential for increased sedation.
  • Antipsychotics: May enhance central nervous system depression.

Frequently Asked Questions

Fresofol 1% LCT is used for the induction and maintenance of general anesthesia and procedural sedation. It is administered intravenously to achieve rapid sedation and unconsciousness for surgical procedures and diagnostic or therapeutic interventions.

Propofol IP works by positively modulating the GABA_A receptor, which enhances the inhibitory effects of the neurotransmitter GABA. This leads to central nervous system depression, resulting in sedation and anesthesia. The rapid onset and short duration of action make it suitable for both induction and maintenance of anesthesia.

The dosage of Fresofol 1% LCT is determined by a healthcare professional based on the patient's condition, age, and response to treatment. It is typically administered intravenously, with the dose adjusted to achieve the desired level of sedation or anesthesia.

The safety of Fresofol 1% LCT during pregnancy has not been established. It should be used during pregnancy only if clearly needed, and under the supervision of a healthcare professional. Pregnant women should discuss the potential risks and benefits with their doctor.

To order Fresofol 1% LCT from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets and will ask the buyer to confirm trade or institutional credentials. The team will reply with pricing, availability, shipping, and the import paperwork.

Fresofol 1% LCT is known for its rapid onset and short duration of action, making it suitable for both induction and maintenance of anesthesia. Compared to other anesthetics, it has a quicker recovery time and is less likely to cause postoperative nausea and vomiting. However, the choice of anesthetic depends on the specific needs of the patient and the procedure.

Fresofol 1% LCT should be stored at 2-8°C, kept refrigerated, and protected from light. It should not be frozen or shaken. Proper storage and handling are essential to maintain the efficacy and safety of the medication.

Fresofol 1% LCT is administered intravenously by trained healthcare professionals. The dosage and administration method are determined by the patient's condition and the specific requirements of the procedure. It is typically given as a bolus or continuous infusion.

The most serious risks associated with Fresofol 1% LCT include anaphylaxis, apnea, and bradycardia. Patients should be closely monitored for signs of severe allergic reactions, respiratory depression, and abnormal heart rhythms. Immediate medical attention is required if any of these serious side effects occur.

Fresofol 1% LCT should not be used by patients with known hypersensitivity to Propofol IP or any of its components. It should be used with caution in patients with cardiovascular or respiratory conditions. Pregnant women should use it only if clearly needed, and under the supervision of a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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