Product image of Glucagen (Glucagon) supplied by GNH India

Glucagen

Active Ingredient:
Glucagon
Origin:
EU

Glucagen (Glucagon)

Glucagen is a glucagon injection solution supplied in a liquid form for intramuscular, intravenous, or subcutaneous administration. It contains the peptide hormone glucagon as the active ingredient and is marketed in the European Union as a prescription product. Glucagen is used to rapidly raise blood glucose levels in individuals experiencing severe hypoglycemia when oral carbohydrate intake is not feasible. Store according to label instructions and keep out of reach of children.

Manufacturer / TM Owner

Novo Nordisk Hellas Ltd.

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Indications & Clinical Uses

Glucagen is indicated for the emergency treatment of severe hypoglycemia in patients who are unable to ingest carbohydrates orally.

  • Adults and children with type 1 or type 2 diabetes experiencing severe hypoglycemia.
  • Situations where rapid glucose elevation is required, such as after insulin overdose.
  • Use when glucagon is preferred over oral glucose due to unconsciousness or seizures.
  • Administration by trained healthcare professionals or caregivers in a medical emergency setting.

Side Effects

The safety profile of glucagon injection includes both common, generally mild reactions and rare, potentially serious events.

Common

  • Nausea or vomiting.
  • Flushing or warmth sensation.
  • Headache.
  • Transient increase in heart rate.

Serious

  • Severe allergic reaction (anaphylaxis) with rash, swelling, or difficulty breathing.
  • Hypotension or cardiovascular collapse.
  • Persistent hyperglycemia requiring medical attention.
  • Injection site necrosis (rare).

Precautions & Warnings

When using Glucagen, several precautions should be observed to ensure safe and effective treatment.

  • Verify the diagnosis of severe hypoglycemia before administration.
  • Use only the prescribed concentration and volume; do not dilute the solution.
  • Ensure proper technique for intramuscular, intravenous, or subcutaneous injection.
  • Store the product at recommended temperature and protect from light.
  • Keep a record of each administration for follow‑up care.
  • Do not reuse the syringe or needle.
  • Seek medical evaluation after the emergency episode.

Avoid Interactions

Glucagon may interact with certain medications, affecting its efficacy or safety.

Avoid

  • Beta‑blockers, which can blunt the glycogenolytic response.
  • Long‑acting insulin analogues that may prolong hypoglycemia.
  • Somatostatin analogues that inhibit glucagon action.

Use with caution

  • Oral hypoglycemic agents (e.g., sulfonylureas) that increase risk of recurrent hypoglycemia.
  • Catecholamine‑releasing drugs that may amplify cardiovascular effects.
  • Medications that affect hepatic glycogen stores, such as corticosteroids.

Frequently Asked Questions

Glucagen is a glucagon injection solution that stimulates hepatic glycogenolysis and gluconeogenesis, quickly raising blood glucose levels in people with severe hypoglycemia.

Glucagen should be given when a patient with diabetes has severe hypoglycemia and cannot safely consume oral carbohydrates, such as when unconscious or having seizures.

Glucagen can be administered intramuscularly, intravenously, or subcutaneously, depending on the clinical situation and provider training.

Yes, Glucagen is classified as a prescription‑only medication throughout the European Union.

Glucagen is approved for use in both adults and children with type 1 or type 2 diabetes who experience severe hypoglycemia.

Common side effects include nausea, vomiting, flushing, a feeling of warmth, headache, and a temporary increase in heart rate.

Serious reactions such as anaphylaxis, severe hypotension, cardiovascular collapse, persistent hyperglycemia, or injection‑site necrosis should be treated as medical emergencies.

Store Glucagen at the temperature recommended on the label, protect it from light, and keep it out of reach of children.

Avoid using Glucagen together with beta‑blockers, long‑acting insulin analogues, or somatostatin analogues, as these can reduce its effectiveness.

Use caution when Glucagen is taken with sulfonylureas, catecholamine‑releasing agents, or corticosteroids, because they may alter glucose metabolism or cardiovascular response.

No dilution is required; the product is supplied as a ready‑to‑use solution at the appropriate concentration for injection.

After administering Glucagen, the patient should receive medical evaluation to monitor glucose levels and address the underlying cause of hypoglycemia.

Published by GNH India Pharmaceuticals Limited

Last updated:

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