Glucagen Hypokit (Glucagon)

Glucagen Hypokit is indicated for the emergency treatment of severe hypoglycemia when rapid restoration of blood glucose is required.

• Acute hypoglycemic episodes in patients with diabetes receiving insulin or insulin secretagogues.
• Situations where oral glucose administration is not feasible, such as unconsciousness or seizures.
• Use by trained medical personnel or caregivers in community or hospital settings.
• As a rescue medication for individuals with known glucagon deficiency or adrenal insufficiency‑related hypoglycemia.

The safety profile of glucagon injection includes both frequently observed and less common adverse reactions.

Common

• Nausea or vomiting
• Flushing or warmth at the injection site
• Headache
• Transient rise in blood pressure
• Dizziness
• Tachycardia

Serious

• Severe allergic reaction (anaphylaxis)
• Cardiac arrhythmia in patients with pre‑existing heart disease
• Hypotension or shock in rare cases
• Pancreatitis
• Seizure

When prescribing or administering Glucagen Hypokit, clinicians should consider several precautionary measures to ensure safe use.

• Verify the patient’s diagnosis of severe hypoglycemia before injection.
• Assess for known hypersensitivity to glucagon or any excipients.
• Use caution in patients with pheochromocytoma or adrenal insufficiency.
• Monitor cardiovascular status, especially in individuals with coronary artery disease.
• Avoid repeated dosing within a short interval unless medically justified.
• Ensure proper storage conditions, protecting the product from light and extreme temperatures.

Glucagon may interact with other medications, affecting its efficacy or safety profile.

Avoid

• Beta‑blockers, which can blunt the hyperglycemic response.
• Insulin or insulin secretagogues administered shortly after glucagon, risking rebound hypoglycemia.

Use with caution

• Oral hypoglycemic agents (e.g., sulfonylureas) that may alter glucose dynamics.
• Catecholamine‑releasing drugs such as epinephrine, which can potentiate cardiovascular effects.
• Diuretics that may affect electrolyte balance and fluid status.