Glucagen Hypokit (Glucagon)

Glucagen Hypokit is indicated for the rapid reversal of severe hypoglycemia when oral carbohydrate intake is not possible or effective.

• Acute treatment of insulin‑induced hypoglycemia in diabetic patients.
• Emergency management of hypoglycemia in patients with adrenal insufficiency or other endocrine disorders.
• Use in hospital or pre‑hospital settings when immediate glucose elevation is required.
• Administration by trained personnel during a hypoglycemic crisis.
• Suitable for patients of all ages who can receive an injectable glucagon preparation.

The safety profile of glucagon includes both frequently observed reactions and rare but serious events.

Common

• Nausea, vomiting, or abdominal discomfort that usually resolves quickly.
• Flushing, warmth, or a feeling of heat at the injection site.
• Headache or dizziness occurring shortly after administration.
• Transient increase in blood pressure or heart rate.
• Local injection site pain or bruising that is typically mild and short‑lasting.
• Transient sweating or feeling of anxiety during the glucose‑raising response.

Serious

• Severe allergic reactions such as anaphylaxis, characterized by rash, swelling, or difficulty breathing.
• Cardiac disturbances including arrhythmias, chest pain, or myocardial ischemia, especially in patients with pre‑existing heart disease.
• Hypoglycemia rebound after initial glucose increase, requiring monitoring and possible repeat dosing.

When using Glucagen Hypokit, healthcare providers and patients should observe several precautions to ensure safe and effective administration.

• Verify the diagnosis of severe hypoglycemia before administration.
• Use only with a compatible glucagon delivery device and follow the manufacturer’s instructions.
• Assess for known hypersensitivity to glucagon or any excipients.
• Monitor blood glucose levels after injection to confirm response.
• Avoid use in patients with pheochromocytoma or insulinoma without specialist guidance.
• Store the kit according to label conditions, protecting it from moisture and extreme temperatures.

Glucagon may interact with certain medications or clinical conditions; awareness of these interactions helps prevent adverse outcomes.

Avoid

• Concomitant use of beta‑blockers that may mask typical glucagon‑induced tachycardia.
• Administration with drugs that cause severe hypertension, such as monoamine oxidase inhibitors, without monitoring.

Use with caution

• Patients receiving oral hypoglycemic agents; monitor for recurrent hypoglycemia after glucagon effect wanes.
• Individuals with cardiovascular disease; observe for arrhythmias or chest discomfort.
• Use in pregnant or lactating women only when the benefit outweighs potential risk, as safety data are limited.