Glucagen Hypokit (Glucagon)

Glucagen Hypokit is indicated for the treatment of severe hypoglycemia when rapid glucose elevation is required.

• Emergency reversal of hypoglycemia in patients with insulin‑induced low blood glucose.
• Use in individuals with diabetes who are unconscious or unable to ingest carbohydrates.
• Administration when oral glucose therapy is ineffective or impractical.
• Management of hypoglycemic episodes in hospital or pre‑hospital settings.
• Use in pediatric patients with congenital hyperinsulinism when other therapies fail.
• Administration by trained personnel during ambulance transport for acute hypoglycemic events.

Glucagen Hypokit may cause a range of adverse reactions, most of which are mild and transient.

Common

• Nausea or vomiting, typically occurring shortly after injection
• Flushing or a sensation of warmth, usually transient
• Headache or dizziness, often mild and resolves quickly
• Transient increase in blood pressure, generally not clinically significant

Serious

• Allergic reactions such as rash, itching, swelling, or hives that may require medical attention
• Severe hypoglycemia recurrence if the administered dose does not adequately raise glucose levels
• Cardiovascular events such as arrhythmia or chest pain, particularly in patients with pre‑existing heart disease
• Pancreatitis signs including abdominal pain and elevated enzymes, though rare

When using Glucagen Hypokit, certain precautions should be observed to ensure safe and effective administration.

• Confirm severe hypoglycemia diagnosis before administration; glucagon is not indicated for mild low glucose.
• Avoid intramuscular injection into the gluteal region to reduce risk of nerve injury.
• Do not reuse the pre‑filled kit; discard after a single use.
• Monitor blood glucose levels after injection to assess response and need for additional treatment.
• Exercise caution in patients with pheochromocytoma or insulinoma, as glucagon may exacerbate symptoms.
• Store the kit at controlled room temperature, protecting it from light and moisture.

Glucagen Hypokit can interact with certain medications or substances, influencing its effectiveness or safety profile.

Avoid

• Concurrent use of beta‑blockers, which may mask typical glucagon‑induced tachycardia and affect glucose response.
• Administration together with other hyperglycemic agents that could cause excessive blood glucose elevation.
• Concurrent use of somatostatin analogues, which can inhibit glucagon’s action and reduce efficacy.

Use with caution

• Patients receiving oral anticoagulants, as glucagon may alter platelet function.
• Individuals on monoamine oxidase inhibitors, due to potential cardiovascular effects.
• Pregnant or breastfeeding women, because safety data are limited.
• Patients with cardiovascular disease, as glucagon may increase heart rate and myocardial oxygen demand.