Glucagen, Hypokit (Glucagon)

Glucagen, Hypokit is indicated for emergency treatment of severe hypoglycemia and certain drug overdoses. It is administered when rapid elevation of blood glucose is required.

• Management of severe hypoglycemia in diabetic patients when oral glucose is ineffective or unavailable
• Treatment of hypoglycemia unresponsive to glucagon-like emergency kits
• Reversal of beta‑blocker overdose when conventional therapies are insufficient
• Adjunct therapy in cases of insulin overdose
• Use in emergency settings where rapid glucose restoration is critical

Glucagen, Hypokit may cause a range of side effects, most of which are transient and related to its mechanism of action.

Common

• Nausea or vomiting
• Flushing or warmth sensation
• Headache
• Dizziness
• Local pain or irritation at the injection site
• Transient hyperglycemia

Serious

• Allergic reactions including rash, itching, or swelling
• Severe hyperglycemia requiring medical attention
• Cardiovascular events such as tachycardia or arrhythmia
• Pancreatitis (rare)
• Hypotension (rare)
• Injection site necrosis (very rare)

Before using Glucagen, Hypokit, certain precautions should be considered to ensure safe administration.

• Verify the diagnosis of severe hypoglycemia before injection
• Use only under medical supervision or as directed in emergency protocols
• Assess for known hypersensitivity to glucagon or any excipients
• Caution in patients with pheochromocytoma or insulinoma due to potential exaggerated glucose response
• Monitor blood glucose levels after administration to avoid rebound hyperglycemia
• Store the product according to manufacturer instructions to maintain potency
• Do not reuse needles or syringes to prevent infection

Glucagen, Hypokit can interact with other medications, influencing its effectiveness or safety profile.

Avoid

• Concurrent use of beta‑blockers that may mask typical glucagon side effects such as tachycardia
• High-dose insulin therapy without appropriate monitoring, which may exacerbate hypoglycemia cycles

Use with caution

• Oral hypoglycemic agents (e.g., sulfonylureas) that may increase risk of recurrent hypoglycemia
• Medications that affect hepatic glycogen stores, such as corticosteroids
• Drugs that alter cardiovascular response, including calcium channel blockers
• Anticholinergic agents that may affect gastrointestinal motility and glucagon absorption