Glucofer (Ferrous Gluconate)

Glucofer is indicated for conditions where additional dietary iron is required.

• Treatment of iron deficiency anemia in adults.
• Prevention of iron deficiency in individuals with increased physiological needs, such as menstruating women.
• Support for patients with chronic blood loss, for example due to gastrointestinal bleeding.
• Adjunct to dietary therapy for individuals with low iron intake.
• Management of iron deficiency associated with pregnancy, when advised by a healthcare professional.
• Use in pediatric patients with iron deficiency under medical supervision.
• Supplementation during recovery from surgery or trauma when iron stores are depleted.

Like other oral iron preparations, Glucofer may cause gastrointestinal and systemic effects, most of which are mild, dose‑related, and resolve after continued use or dose adjustment.

Common

• Nausea or mild stomach upset.
• Abdominal cramping or discomfort.
• Constipation, loose stools, or diarrhea.
• Dark or black-colored stools.
• Metallic or unpleasant taste in the mouth.

Serious

• Severe allergic reaction, including rash, itching, swelling of the face or throat, or difficulty breathing.
• Signs of iron overload such as joint pain, persistent abdominal pain, unexplained fatigue, or dark urine.
• Acute toxicity from accidental overdose, presenting with vomiting, severe abdominal pain, and shock.
• Hypotension or cardiovascular instability in patients with pre‑existing heart disease.

Precautions for Glucofer focus on appropriate patient selection, monitoring of iron status, and awareness of conditions that may increase the risk of adverse outcomes.

• Verify iron deficiency with laboratory tests before initiating therapy.
• Use the lowest effective dose and reassess need after 4–6 weeks.
• Caution in patients with inflammatory bowel disease, ulcerative colitis, or other gastrointestinal disorders that affect iron absorption.
• Avoid use in individuals with known hypersensitivity to ferrous gluconate or other iron salts.
• Monitor for signs of iron overload in patients receiving chronic supplementation.
• Pregnant or breastfeeding women should consult a healthcare professional before use.
• Children should only use Glucofer under medical supervision.

Glucofer can interact with certain foods, medications, and supplements that affect iron absorption or increase the risk of adverse effects.

Avoid

• Antacids containing aluminum, magnesium, or calcium taken within two hours of Glucofer, as they reduce iron absorption.
• Tetracycline antibiotics (e.g., doxycycline, minocycline) administered concurrently, which may form insoluble complexes with iron.
• Levothyroxine taken at the same time, potentially decreasing the effectiveness of both agents.

Use with caution

• Proton pump inhibitors or H2 blockers, which may modestly lower iron absorption; spacing doses may help.
• Oral contraceptives or hormone replacement therapy, as iron status can influence efficacy.
• High‑dose vitamin C supplements, which increase iron absorption and may exacerbate gastrointestinal irritation.