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Glucophage

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Glucophage (Metformin Hydrochloride)

Glucophage is a prescription medication that contains metformin hydrochloride, a biguanide oral antidiabetic agent. Marketed in the European Union, it is supplied as an oral tablet, with strengths that may vary. The drug decreases hepatic glucose production and improves peripheral insulin sensitivity, serving as a cornerstone therapy for type 2 diabetes mellitus in adult patients. It is prescribed by healthcare professionals and requires regular blood‑glucose monitoring.

Manufacturer / TM Owner

Merck Gesellschaft Mbh

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Indications & Clinical Uses

Glucophage is indicated for the management of type 2 diabetes mellitus and is used as part of a comprehensive treatment plan.

  • As monotherapy in patients whose diet and exercise are insufficient to control glucose levels.
  • In combination with other oral antidiabetic agents such as sulfonylureas or DPP‑4 inhibitors.
  • As an adjunct to insulin therapy when additional glycemic control is needed.
  • To improve glycemic control in overweight or obese adults with type 2 diabetes.
  • Occasionally prescribed off‑label for polycystic ovary syndrome under specialist supervision.

Side Effects

Glucophage may cause a range of adverse effects; they are generally categorized as common or serious.

Common

  • Gastrointestinal upset such as nausea, abdominal discomfort, and diarrhea.
  • Metallic taste in the mouth.
  • Decreased appetite or modest weight loss.
  • Mild skin rash or itching.

Serious

  • Lactic acidosis, a rare but life‑threatening condition.
  • Severe hypoglycemia when combined with insulin or sulfonylureas.
  • Hepatotoxicity indicated by jaundice or elevated liver enzymes.
  • Persistent vomiting leading to dehydration.

Precautions & Warnings

Before starting Glucophage, certain precautions and warnings should be considered to ensure safe use.

  • Assess renal function; the drug is contraindicated in severe renal impairment.
  • Evaluate liver function and use cautiously in patients with hepatic disease.
  • Monitor for signs of lactic acidosis, especially after surgery or acute illness.
  • Adjust dose in elderly patients due to altered pharmacokinetics.
  • Avoid use in patients with known hypersensitivity to metformin.
  • Review concomitant medications that may affect renal clearance.

Avoid Interactions

Glucophage can interact with other medicines; some combinations should be avoided while others require careful monitoring.

Avoid

  • Alcoholic beverages, which increase the risk of lactic acidosis.
  • Iodinated contrast agents used in imaging, which can impair renal function.

Use with caution

  • Cimetidine and other drugs that reduce renal clearance of metformin.
  • Loop diuretics or thiazides that may affect kidney function.
  • Beta‑blockers that can mask symptoms of hypoglycemia.

Frequently Asked Questions

Glucophage (metformin hydrochloride) lowers blood glucose by decreasing hepatic glucose production and increasing peripheral insulin sensitivity.

Yes, Glucophage is a prescription medication marketed in the EU for the treatment of type 2 diabetes mellitus.

Glucophage is commonly prescribed as a first‑line oral agent for adults with type 2 diabetes, often together with diet and exercise.

The most frequently reported side effects include gastrointestinal symptoms such as nausea, abdominal discomfort, diarrhea, a metallic taste, and mild weight loss.

Lactic acidosis is a rare but serious reaction; patients should seek immediate medical attention if they experience unexplained muscle pain, rapid breathing, or abdominal discomfort.

Yes, renal function should be evaluated because Glucophage is contraindicated in patients with severe renal impairment.

Alcohol can increase the risk of lactic acidosis and should be limited or avoided while using Glucophage.

Glucophage may be combined with insulin to improve glycemic control, but dose adjustments and close monitoring for hypoglycemia are recommended.

Iodinated contrast agents used for imaging studies should be avoided because they can impair renal function and increase the risk of metformin accumulation.

Glucophage is taken orally, usually with meals to reduce gastrointestinal upset; the exact dosing schedule should follow the prescribing clinician’s instructions.

The pregnancy category for Glucophage is listed as unknown; its use during pregnancy should be decided by a healthcare professional based on risk‑benefit assessment.

Glucophage is occasionally prescribed off‑label for polycystic ovary syndrome, but such use should be under specialist supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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