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Glucophage

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Glucophage (Metformin Hydrochloride)

Glucophage is a prescription medication that contains the active ingredient metformin hydrochloride, supplied in oral tablet form. It belongs to the biguanide class of antidiabetic drugs and is marketed in the European Union. Glucophage works by decreasing hepatic glucose production and enhancing peripheral insulin sensitivity, helping to manage blood glucose levels in adults with type 2 diabetes mellitus.

Manufacturer / TM Owner

Merck D.O.O

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Indications & Clinical Uses

Glucophage is indicated for the management of type 2 diabetes mellitus as part of a comprehensive treatment plan that includes diet and exercise.

  • Improves glycemic control in adults with type 2 diabetes.
  • Used as first‑line therapy when lifestyle changes alone are insufficient.
  • May be combined with other oral antidiabetic agents or insulin.
  • Helps reduce fasting plasma glucose and HbA1c levels.
  • Supports long‑term metabolic control when taken consistently.

Side Effects

Glucophage can cause a range of side effects, most of which are mild and transient. Serious adverse events are less common but require medical attention.

Common

  • Gastrointestinal upset such as nausea, diarrhea, or abdominal discomfort.
  • Metallic taste in the mouth.
  • Decreased appetite.
  • Mild headache.
  • Weight loss.

Serious

  • Lactic acidosis, a rare but potentially life‑threatening condition.
  • Severe skin reactions like Stevens‑Johnson syndrome.
  • Hepatotoxicity indicated by elevated liver enzymes.
  • Persistent vomiting leading to dehydration.

Precautions & Warnings

Before starting Glucophage, certain health considerations should be reviewed to minimize risks.

  • Assess renal function; avoid use in severe renal impairment.
  • Monitor liver enzymes periodically, especially in patients with hepatic disease.
  • Evaluate for signs of heart failure, as it may increase lactic acidosis risk.
  • Use caution during pregnancy and breastfeeding; discuss benefits and risks with a healthcare provider.
  • Adjust dose in elderly patients due to altered drug clearance.
  • Ensure adequate hydration and avoid excessive alcohol consumption.

Avoid Interactions

Glucophage may interact with several medications, affecting its efficacy or safety profile.

Avoid

  • Iodinated contrast agents used in imaging studies, which can precipitate acute kidney injury.
  • Cimetidine, which can increase metformin plasma concentrations.
  • Certain diuretics that may impair renal function.

Use with caution

  • Alcohol, as it raises the risk of lactic acidosis.
  • Beta‑blockers, which may mask hypoglycemia symptoms.
  • Corticosteroids, which can elevate blood glucose levels.
  • Other antidiabetic agents, requiring dose adjustments to avoid hypoglycemia.

Frequently Asked Questions

Glucophage reduces hepatic glucose production and improves peripheral insulin sensitivity, helping lower blood glucose levels.

Glucophage should be avoided or dose‑adjusted in patients with moderate to severe renal impairment; renal function should be evaluated before prescribing.

The safety of Glucophage during pregnancy is not fully established; clinicians weigh potential benefits against risks and may consider alternative therapies.

Common GI side effects include nausea, diarrhea, abdominal discomfort, and a metallic taste.

Liver enzymes are typically checked before starting therapy and periodically thereafter, especially in patients with existing liver disease.

Excessive alcohol can increase the risk of lactic acidosis when taking Glucophage, so alcohol intake should be limited.

Yes, Glucophage can be used alongside insulin, but dose adjustments may be needed to avoid hypoglycemia.

Take the missed dose as soon as you remember unless it is close to the time of the next scheduled dose; do not double the dose.

Lactic acidosis is a rare but serious condition that can occur if metformin accumulates, especially in patients with renal or hepatic impairment.

No specific diet is required, but maintaining a balanced diet and regular meals helps optimize blood glucose control.

Glucophage belongs to the biguanide class and primarily reduces liver glucose output, whereas other agents may stimulate insulin release or affect carbohydrate absorption.

Baseline and periodic monitoring of renal function, liver enzymes, and blood glucose levels are recommended to assess efficacy and safety.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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