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Glucophage Sr

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Glucophage Sr (Metformin Hydrochloride)

Glucophage Sr is a prescription medication that contains the active ingredient metformin hydrochloride. It is supplied as an oral tablet (strength not specified) and is marketed in the European Union. As a biguanide antidiabetic drug, Glucophage Sr lowers hepatic glucose production and improves peripheral insulin sensitivity, and it is used in adults with type 2 diabetes mellitus as part of a comprehensive individualized clinical treatment plan.

Manufacturer / TM Owner

Merck A.E.

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Indications & Clinical Uses

Glucophage Sr is indicated for the management of type 2 diabetes mellitus in adults.

  • As monotherapy when diet and exercise are insufficient.
  • In combination with other oral antidiabetic agents.
  • As adjunct to insulin therapy when additional glucose control is needed.
  • To improve glycemic control as part of a comprehensive diabetes management program.
  • When combined with lifestyle modifications to achieve target HbA1c levels.
  • As part of fixed‑dose combinations with other oral agents, if clinically appropriate.

Side Effects

Side effects reported with metformin-containing products vary in frequency and severity.

Common

  • Gastrointestinal upset such as nausea, abdominal discomfort, or diarrhea.
  • Metallic taste in the mouth.
  • Mild headache.
  • Decreased appetite.

Serious

  • Lactic acidosis, a rare but potentially fatal metabolic complication.
  • Severe skin reactions including Stevens‑Johnson syndrome.
  • Hepatotoxicity signs such as jaundice.
  • Persistent vomiting leading to dehydration.

Precautions & Warnings

Before prescribing Glucophage Sr, clinicians consider several precautionary factors to minimize risks.

  • Assess renal function; metformin is contraindicated in severe renal impairment.
  • Evaluate hepatic function because liver disease can increase lactic acidosis risk.
  • Review history of alcohol abuse, which may predispose to metabolic acidosis.
  • Use caution in patients over 80 years of age or with low body weight.
  • Discontinue before any radiographic studies using iodinated contrast agents.
  • Monitor vitamin B12 levels during long‑term therapy.

Avoid Interactions

Metformin can interact with a range of medicines, affecting its efficacy or safety profile.

Avoid

  • Iodinated contrast media used for imaging studies.
  • Cimetidine, which may increase metformin plasma concentrations.
  • Certain antiretroviral drugs (e.g., didanosine) that raise the risk of lactic acidosis.

Use with caution

  • Diuretics that may affect renal function.
  • ACE inhibitors or ARBs that can alter kidney perfusion.
  • Beta‑blockers that may mask hypoglycemia symptoms.

Frequently Asked Questions

Glucophage Sr contains metformin, which decreases hepatic glucose production and increases peripheral insulin sensitivity, helping to lower blood sugar levels.

Glucophage Sr is a specific brand of metformin hydrochloride marketed in the EU; its formulation, tablet characteristics, and excipients may differ from other brands, but the active ingredient and therapeutic effect are the same.

Metformin use requires assessment of renal function. In mild impairment, a clinician may adjust therapy or monitor closely, but severe renal dysfunction is a contraindication.

Typical gastrointestinal effects include nausea, abdominal discomfort, diarrhea, and a metallic taste in the mouth, usually occurring early in treatment.

While specific dosing instructions are not provided here, metformin is generally taken with meals to reduce gastrointestinal upset.

The safety of metformin in pregnancy depends on clinical judgment; it is sometimes used for gestational diabetes, but a healthcare provider should evaluate risks and benefits.

Regular monitoring of blood glucose, renal function, liver enzymes, and vitamin B12 levels during long‑term therapy is commonly advised.

Excessive alcohol intake can increase the risk of lactic acidosis when taking metformin, so patients are advised to limit alcohol consumption.

Yes, metformin can be used as an adjunct to insulin when additional glucose control is needed, under medical supervision.

Symptoms such as rapid breathing, muscle pain, abdominal discomfort, dizziness, or unexplained fatigue may signal lactic acidosis and require immediate medical attention.

Metformin typically begins to lower blood glucose within a few days, with the full effect often observed after several weeks of consistent use.

Certain OTC drugs, such as cimetidine or high‑dose vitamin B12 supplements, may affect metformin levels; patients should discuss all OTC use with their healthcare provider.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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