Glucorex Sr (Metformin Hydrochloride)

Glucorex Sr is indicated for the long‑term management of hyperglycemia in adults diagnosed with type 2 diabetes mellitus, typically as part of a comprehensive treatment plan that includes diet and exercise.

• Improves glycemic control when combined with lifestyle modifications.
• May be used as initial oral therapy for newly diagnosed patients.
• Can be added to other antidiabetic agents if monotherapy is insufficient.
• Helps reduce hepatic glucose production and increase peripheral insulin sensitivity.
• Often prescribed when weight management is a treatment goal.

Glucorex Sr may cause a range of side effects; most are mild and transient, while a few require prompt medical attention.

Common

• Nausea or upset stomach
• Diarrhea or loose stools
• Metallic taste in the mouth
• Decreased appetite or mild weight loss
• Abdominal discomfort or cramping

Serious

• Lactic acidosis, a rare but life‑threatening condition
• Severe skin reactions such as Stevens‑Johnson syndrome
• Persistent vomiting leading to dehydration
• Hypoglycemia when combined with other glucose‑lowering drugs
• Elevated liver enzymes

Before starting Glucorex Sr, patients should consider several precautionary measures to minimize risks and ensure safe use.

• Assess kidney function; avoid use in severe renal impairment.
• Monitor liver enzymes periodically, especially in patients with hepatic disease.
• Use with caution in older adults due to increased risk of lactic acidosis.
• Discontinue before any radiographic procedures that use iodinated contrast agents.
• Review all current medications to identify potential interactions.
• Educate patients on recognizing symptoms of lactic acidosis.
• Advise against excessive alcohol consumption while on therapy.

Glucorex Sr can interact with other medicines, affecting its efficacy or safety profile.

Avoid

• Iodinated contrast media used for imaging studies.
• Cimetidine, which can increase metformin plasma concentrations.
• Certain diuretics that may impair renal clearance.

Use with caution

• Other antidiabetic agents, especially insulin or sulfonylureas, due to hypoglycemia risk.
• ACE inhibitors or ARBs in patients with renal dysfunction.
• Alcohol, which can increase the risk of lactic acidosis.