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Glucose 10% Labesfal

Active Ingredient:
Glucose
Origin:
EU

Glucose 10% Labesfal (Glucose)

Glucose 10% Labesfal is an intravenous solution containing 10 % w/v glucose as the sole active ingredient. It is supplied as a sterile, aqueous carbohydrate solution intended for parenteral administration. The product is classified as a carbohydrate solution and is marketed in the European Union for prescription use. It provides an exogenous source of glucose for patients requiring fluid, electrolyte, or nutritional support in clinical practice.

Manufacturer / TM Owner

Labesfal Laboratorios Almiro, S.A.

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Indications & Clinical Uses

Glucose 10% Labesfal is used when rapid elevation of plasma glucose is required or when carbohydrate calories are needed as part of parenteral therapy. Indications include:

  • Treatment of hypoglycemia in adults and children.
  • Component of total parenteral nutrition regimens.
  • Fluid and electrolyte replacement in patients unable to tolerate oral intake.
  • Support during perioperative periods when fasting is required.
  • Management of metabolic disorders that limit endogenous glucose production.

Side Effects

Adverse reactions to Glucose 10% Labesfal are generally related to the infusion itself or to rapid changes in blood glucose.

Common

  • Local irritation at the infusion site.
  • Mild hyperglycemia.
  • Nausea or vomiting.
  • Headache.

Serious

  • Severe hyperglycemia with osmotic diuresis.
  • Electrolyte imbalance (e.g., hyponatremia).
  • Allergic reaction such as urticaria or anaphylaxis.
  • Volume overload leading to pulmonary edema.

Precautions & Warnings

Before initiating therapy with Glucose 10% Labesfal, clinicians should evaluate patient-specific factors and monitor relevant parameters.

  • Assess baseline blood glucose and adjust infusion rate accordingly.
  • Monitor electrolytes, especially sodium and potassium, during prolonged administration.
  • Use caution in patients with renal or cardiac insufficiency due to risk of fluid overload.
  • Avoid rapid infusion in neonates and infants.
  • Consider compatibility with other IV medications; do not mix with calcium‑containing solutions.
  • Discontinue or adjust dose if signs of hyperglycemia develop.

Avoid Interactions

Glucose 10% Labesfal may affect the pharmacokinetics or pharmacodynamics of certain co‑administered drugs.

Avoid

  • Concurrent use with insulin bolus doses without appropriate glucose monitoring.
  • Simultaneous infusion of high‑dose potassium chloride, which may precipitate in the solution.

Use with caution

  • Diuretics that alter electrolyte balance, requiring closer monitoring.
  • Beta‑blockers that can mask hypoglycemia symptoms.
  • Corticosteroids that increase glucose production, potentially leading to hyperglycemia.
  • Oral hypoglycemic agents, as intravenous glucose can counteract their effect.

Frequently Asked Questions

Glucose 10% Labesfal contains glucose at a concentration of 10 % weight/volume (w/v), meaning 10 g of glucose per 100 mL of solution.

The product is supplied as a sterile aqueous solution for intravenous infusion. It is typically administered through a peripheral or central venous line, with the infusion rate adjusted to the patient’s clinical needs and blood glucose monitoring.

It is indicated for the treatment of hypoglycemia, as a source of carbohydrate calories in total parenteral nutrition, and for fluid and electrolyte replacement when oral intake is not possible.

Blood glucose levels should be checked regularly, and electrolytes (especially sodium and potassium) should be monitored during prolonged infusions. Fluid balance and signs of volume overload also need observation.

Glucose 10% Labesfal should not be mixed with calcium‑containing solutions because of the risk of precipitation. Compatibility with other medications should be verified before co‑administration.

Common adverse effects include mild hyperglycemia, local irritation at the infusion site, nausea, vomiting, and headache.

Glucose 10% Labesfal provides twice the glucose concentration of a 5 % dextrose solution, delivering more calories per volume and being used when a higher glucose load is required.

It may be used in children under careful monitoring of blood glucose and infusion rate. Rapid infusion should be avoided in neonates and infants.

Patients with renal dysfunction are at increased risk of fluid overload and electrolyte disturbances; infusion rates should be reduced and fluid balance closely monitored.

If hyperglycemia develops, the infusion rate should be decreased or temporarily stopped, and insulin therapy may be initiated according to institutional protocols.

The solution should be stored at controlled room temperature, protected from light, and used before the expiration date indicated on the packaging.

Glucose 10% Labesfal is not recommended for direct mixing with blood products because the high glucose concentration can affect red blood cell viability.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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