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Glucose 5% G/V

Active Ingredient:
Glucose Monohydrate
Origin:
EU

Glucose 5% G/V (Glucose Monohydrate)

Glucose 5% G/V is an intravenous solution for injection that contains 5% w/v glucose monohydrate as the active ingredient. It is classified as an excipient/carbohydrate solution and is marketed in the European Union for use under prescription. The product provides a readily available source of glucose for energy and fluid volume expansion when administered intravenously.

Manufacturer / TM Owner

B.Braun Melsungen Ag

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Indications & Clinical Uses

Glucose 5% G/V is employed in clinical settings to address several metabolic and fluid needs. It is commonly used for:

  • Treatment of hypoglycemia in patients unable to take oral glucose.
  • Fluid and electrolyte replacement during dehydration or surgery.
  • Parenteral nutrition as a carbohydrate source.
  • Maintenance of blood glucose levels in critically ill or peri‑operative patients.
  • Support for patients receiving total parenteral nutrition (TPN).

Side Effects

Glucose 5% G/V is generally well tolerated, but adverse reactions can occur. The frequency and severity of side effects vary.

Common

  • Hyperglycemia or elevated blood glucose levels.
  • Local irritation at the infusion site.
  • Mild nausea or vomiting.
  • Headache.
  • Transient electrolyte imbalance (e.g., low potassium).

Serious

  • Severe hyperglycemia leading to osmotic diuresis.
  • Allergic reaction or anaphylaxis.
  • Volume overload causing pulmonary edema.
  • Metabolic acidosis in susceptible patients.

Precautions & Warnings

Glucose 5% G/V should be administered with careful clinical assessment. Important considerations include:

  • Monitoring blood glucose levels regularly during infusion.
  • Adjusting dosage in patients with diabetes mellitus or impaired glucose tolerance.
  • Assessing fluid status to avoid volume overload, especially in heart failure or renal impairment.
  • Using caution in patients with electrolyte disturbances, particularly hypokalemia.
  • Avoiding rapid infusion rates that may cause hyperosmolar complications.
  • Ensuring aseptic technique to prevent catheter‑related infections.

Avoid Interactions

Glucose 5% G/V may interact with other medications or clinical conditions. Interactions to note are:

Avoid

  • Concurrent use of high‑dose insulin without glucose monitoring, which can precipitate severe hypoglycemia.
  • Co‑administration with other hypertonic carbohydrate solutions that may cause excessive hyperglycemia.

Use with caution

  • Diuretics that affect electrolyte balance, requiring close monitoring.
  • Beta‑blockers, which can mask symptoms of hypoglycemia.
  • Corticosteroids, as they may increase glucose requirements.
  • Medications that affect renal function, such as ACE inhibitors, due to fluid balance considerations.

Frequently Asked Questions

Glucose 5% G/V is primarily indicated for the treatment of hypoglycemia and as a source of carbohydrate in fluid and electrolyte replacement or parenteral nutrition.

The product is supplied as a sterile solution for injection and is administered intravenously, typically through a peripheral or central venous catheter.

Yes, but blood glucose levels should be closely monitored and the infusion rate adjusted to avoid hyperglycemia in diabetic patients.

Regular monitoring of blood glucose, electrolytes, and fluid balance is recommended to detect hyperglycemia, electrolyte shifts, or volume overload.

Glucose 5% G/V can be used in pediatric patients under medical supervision, with dosing and monitoring adjusted for age and weight.

Common side effects include transient hyperglycemia, mild nausea, headache, local infusion site irritation, and mild electrolyte disturbances.

Serious reactions may include severe hyperglycemia, allergic reactions or anaphylaxis, volume overload leading to pulmonary edema, and metabolic acidosis.

The solution should be stored at controlled room temperature, protected from light, and used before the expiration date indicated on the packaging.

It can be combined with compatible IV fluids, but compatibility should be confirmed and the mixture administered according to institutional protocols.

Contraindications include known hypersensitivity to glucose monohydrate and conditions where rapid volume expansion could be harmful, such as severe heart failure.

Glucose 5% G/V is classified as an excipient/carbohydrate solution used therapeutically for its metabolic and volume‑expanding properties.

The ATC code for this product is B05BA01, which designates it as a glucose solution.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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