Product image of Glucose En Natriumchloride (Sodium Chloride, Glucose Monohydrate) supplied by GNH India

Glucose En Natriumchloride

Active Ingredient:
Sodium Chloride, Glucose Monohydrate
Origin:
EU

Glucose En Natriumchloride (Sodium Chloride, Glucose Monohydrate)

Glucose En Natriumchloride is an intravenous injection solution that combines sodium chloride and glucose monohydrate. It is supplied without a specified strength and is marketed in the European Union for use under prescription. The formulation is designed to deliver both an electrolyte and a carbohydrate source directly into the bloodstream, supporting fluid balance and energy needs in clinical settings.

Manufacturer / TM Owner

Fresenius Kabi Nederland B.V.

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Indications & Clinical Uses

Glucose En Natriumchloride is indicated for several clinical situations where fluid, electrolyte, and glucose replacement are required.

  • Restoration of intravascular volume in patients with dehydration or blood loss.
  • Correction of hyponatremia or low sodium levels.
  • Management of hypoglycemia when oral glucose is not feasible.
  • Supplementation of parenteral nutrition regimens.
  • Support during surgical procedures or intensive care where intravenous fluids are needed.
  • Use as a carrier for other intravenous medications when compatible.

Side Effects

Side effects of Glucose En Natriumchloride may vary in frequency and severity.

Common

  • Local irritation or pain at the injection site.
  • Mild hyperglycemia or elevated blood glucose levels.
  • Transient increase in serum sodium concentration.
  • Nausea or mild gastrointestinal discomfort.
  • Headache or dizziness related to fluid shifts.

Serious

  • Severe hypernatremia leading to neurological symptoms.
  • Acute pulmonary edema from rapid volume overload.
  • Allergic reaction or anaphylaxis.
  • Significant hyperglycemia requiring medical intervention.
  • Electrolyte imbalance causing cardiac arrhythmias.

Precautions & Warnings

When using Glucose En Natriumchloride, clinicians should consider several safety measures.

  • Assess baseline electrolyte levels and blood glucose before administration.
  • Adjust infusion rate in patients with heart failure or renal impairment to avoid fluid overload.
  • Monitor serum sodium and glucose regularly during therapy.
  • Use caution in patients with known hypersensitivity to sodium chloride or glucose solutions.
  • Avoid rapid bolus administration unless specifically indicated.
  • Ensure proper aseptic technique to prevent infection at the infusion site.
  • Review concomitant medications that may affect fluid or electrolyte balance.

Avoid Interactions

Glucose En Natriumchloride can interact with other drugs, influencing safety and efficacy.

Avoid

  • Concurrent use of high-dose insulin without glucose monitoring, which may precipitate severe hypoglycemia.
  • Administration with hypertonic saline solutions that could exacerbate hypernatremia.

Use with caution

  • Diuretics that increase sodium loss, requiring closer electrolyte monitoring.
  • Medications that affect cardiac conduction (e.g., digoxin) when electrolyte shifts are possible.
  • Steroids or catecholamines that raise blood glucose levels.
  • Renal replacement therapies that alter fluid and electrolyte status.
  • Blood products that may affect volume status when given together.

Frequently Asked Questions

The injection is used to replace both fluid volume and electrolytes, while also providing a source of glucose for patients who need intravenous support.

It is commonly given for dehydration, blood loss, hyponatremia, hypoglycemia, and as part of parenteral nutrition regimens.

Unlike plain saline, this formulation also contains glucose monohydrate, offering both an electrolyte and a carbohydrate source in a single infusion.

Use in children is possible but requires careful dosing and monitoring of glucose and electrolyte levels by a qualified healthcare professional.

Regular checks of serum sodium, glucose, and overall fluid balance are recommended, especially in patients with cardiac or renal conditions.

Yes, especially if administered rapidly or in large volumes; blood glucose should be monitored to detect any significant rise.

Symptoms may include rash, itching, swelling, difficulty breathing, or anaphylaxis, and require immediate medical attention.

Yes, a slower infusion rate is advised to avoid fluid overload and potential pulmonary edema in heart‑failure patients.

Compatibility should be verified; some drugs may be incompatible or alter the solution’s electrolyte balance.

No, it is a prescription‑only medication and must be administered under medical supervision.

The infusion should be stopped, and the patient should receive appropriate medical management to lower serum sodium safely.

It should be stored according to the manufacturer’s instructions, typically in a cool, dry place protected from light, and used before the expiration date.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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