Glucose-Infusionslösung 5 (Glucose Monohydrate)

Glucose-Infusionslösung 5 is employed in clinical settings where rapid elevation of plasma glucose is required. Typical applications include:

• Treatment of hypoglycaemia in patients unable to take oral glucose.
• Provision of caloric support during peri‑operative fasting.
• Maintenance of blood glucose levels in critically ill or trauma patients.
• Use as a carrier for compatible intravenous medications.
• Support during parenteral nutrition regimens when carbohydrate supplementation is needed.

Adverse reactions to Glucose-Infusionslösung 5 are generally related to the infusion process and the glucose load. They are categorized as follows:

Common

• Local irritation or pain at the infusion site.
• Mild hyperglycaemia when administered in excess.
• Nausea or vomiting secondary to rapid glucose infusion.
• Electrolyte shifts, particularly low potassium levels.

Serious

• Severe hyperglycaemia leading to osmotic diuresis.
• Fluid overload or pulmonary oedema in patients with compromised cardiac function.
• Hyperosmolar hyperglycaemic state in susceptible individuals.
• Allergic reactions such as urticaria or anaphylaxis, though rare.

When using Glucose-Infusionslösung 5, clinicians should observe several safety measures. Important considerations include:

• Assess baseline blood glucose and monitor levels frequently during infusion.
• Adjust infusion rates in patients with renal or cardiac insufficiency to avoid fluid overload.
• Use caution in diabetic patients to prevent excessive hyperglycaemia.
• Verify compatibility with other intravenous solutions before co‑administration.
• Ensure aseptic technique to reduce risk of infection at the infusion site.
• Review patient history for known hypersensitivity to glucose solutions.

Glucose-Infusionslösung 5 may interact with other agents administered intravenously. Interactions are grouped as follows:

Avoid

• Co‑administration with high‑dose insulin without close glucose monitoring.
• Simultaneous infusion of potassium chloride solutions, which can exacerbate hyperkalemia.

Use with caution

• Concurrent use of diuretics that may alter electrolyte balance.
• Administration alongside other hyperosmolar solutions, which can increase risk of fluid shifts.
• Use with catecholamines that may affect glucose metabolism.
• Combination with glucocorticoids, which can raise blood glucose levels.