Glukóza B. Braun (Glucose Monohydrate)

Glukóza B. Braun is indicated for several clinical situations where rapid provision of glucose and fluid balance is required.

• Treatment of hypoglycemia when oral glucose is not feasible.
• Component of parenteral nutrition regimens for patients unable to receive enteral feeding.
• Fluid and electrolyte replacement in perioperative or critical‑care settings.
• Intraoperative energy source to maintain blood glucose during surgery.
• Dilution medium for certain intravenous medications requiring a carbohydrate carrier.
• Support of metabolic demands in patients with prolonged fasting or catabolic states.

Adverse reactions to Glukóza B. Braun are generally related to its osmolarity, glucose content, and infusion rate.

Common

• Mild hyperglycemia, especially in patients with impaired glucose tolerance.
• Local irritation or pain at the infusion site.
• Nausea or transient vomiting.
• Electrolyte shifts such as mild hyponatremia.
• Transient headache or dizziness.
• Mild metabolic acidosis in high infusion rates.

Serious

• Severe hyperglycemia leading to osmotic diuresis.
• Hyperosmolar hyperglycemic state (HHS) in susceptible individuals.
• Fluid overload causing pulmonary edema.
• Allergic reactions ranging from urticaria to anaphylaxis.
• Severe electrolyte disturbances such as hyperkalemia.
• Rapid rise in serum osmolality with neurologic symptoms.

When prescribing Glukóza B. Braun, clinicians should evaluate patient-specific factors and monitor relevant parameters to minimize risks.

• Assess blood glucose levels before and during infusion, adjusting rate as needed.
• Use caution in patients with diabetes mellitus or impaired insulin response.
• Monitor fluid balance to avoid overload, especially in heart or renal failure.
• Check electrolyte status, particularly sodium and potassium, before administration.
• Avoid rapid bolus injections; infuse over a controlled period.
• Consider compatibility with other IV solutions; do not mix with calcium‑containing fluids.
• Pregnant or lactating patients should be evaluated individually due to limited safety data.

Glukóza B. Braun may interact with other intravenous agents or affect the pharmacodynamics of concurrent medications.

Avoid

• Co‑administration with calcium‑containing solutions, which can precipitate calcium gluconate.
• Simultaneous infusion with high‑dose insulin without appropriate glucose monitoring.
• Mixing with hypertonic saline solutions, which can increase osmolar load.

Use with caution

• Concurrent use of diuretics that may exacerbate electrolyte shifts.
• Beta‑blockers that mask hypoglycemia symptoms.
• Corticosteroids that increase glucose production.
• Vasopressors that may alter peripheral perfusion and affect infusion site tolerance.
• Concurrent total parenteral nutrition formulations, requiring careful monitoring of total carbohydrate load.