Product image of Glucosio Monico (Glucose Monohydrate) supplied by GNH India

Glucosio Monico

Active Ingredient:
Glucose Monohydrate
Origin:
EU

Glucosio Monico (Glucose Monohydrate)

Glucosio Monico is an intravenous solution that contains glucose monohydrate as its sole active ingredient. Marketed in the European Union and supplied by prescription only, the product provides a carbohydrate source for parenteral nutrition and rapid correction of low blood glucose. It is presented as a sterile solution for intravenous infusion, with no specified strength disclosed in the label and is intended for use under medical supervision.

Manufacturer / TM Owner

Monico S.P.A.

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Indications & Clinical Uses

Glucosio Monico is indicated for clinical situations where an immediate source of glucose is required.

  • Treatment of hypoglycemia in patients unable to take oral glucose.
  • Provision of carbohydrate calories as part of total parenteral nutrition (TPN).
  • Support of fluid and electrolyte balance during peri‑operative care.
  • Replacement of glucose losses in patients with prolonged fasting or severe catabolism.
  • Adjunctive therapy for patients receiving insulin infusions to prevent rapid glucose declines.

Side Effects

Adverse reactions to Glucosio Monico are generally related to the intravenous administration of a glucose solution.

Common

  • Mild rise in plasma glucose levels when administered in larger volumes than required.
  • Local irritation, redness, or pain at the catheter insertion site.
  • Nausea or brief vomiting if the infusion rate is rapid.
  • Transient headache or dizziness during or shortly after infusion.

Serious

  • Marked hyperglycemia that may progress to osmotic diuresis.
  • Allergic or anaphylactic response to the solution constituents.
  • Fluid overload with risk of pulmonary edema, especially in patients with cardiac dysfunction.
  • Significant electrolyte imbalance such as severe hypokalemia or hyponatremia.

Precautions & Warnings

When prescribing Glucosio Monico, clinicians should consider several precautionary measures to ensure safe use.

  • Assess baseline blood glucose and adjust infusion rate to avoid hyperglycemia.
  • Monitor electrolyte levels, particularly sodium and potassium, during therapy.
  • Use caution in patients with renal or hepatic impairment due to altered glucose metabolism.
  • Evaluate cardiac function before infusion in individuals at risk for fluid overload.
  • Avoid rapid infusion in neonates and infants to prevent metabolic disturbances.
  • Document any history of allergy to carbohydrate solutions.

Avoid Interactions

Glucosio Monico may interact with other agents that affect glucose homeostasis or fluid balance.

Avoid

  • Concurrent high‑dose insulin therapy without glucose monitoring, which can precipitate severe hypoglycemia.
  • Co‑administration with other hypertonic glucose solutions, which may cause excessive hyperglycemia.

Use with caution

  • Diuretics that alter electrolyte status, requiring close monitoring of sodium and potassium.
  • Corticosteroids that increase glucose production, potentially enhancing hyperglycemic risk.
  • Cardiac medications (e.g., digoxin) in patients prone to fluid overload, necessitating careful volume assessment.

Frequently Asked Questions

Glucosio Monico is a sterile intravenous solution that contains glucose monohydrate as its only active ingredient. It is supplied as a clear, aqueous solution intended for infusion into the bloodstream under medical supervision.

It is commonly prescribed for rapid correction of hypoglycemia, as a carbohydrate source in total parenteral nutrition, and for fluid and electrolyte replenishment during peri‑operative care or prolonged fasting.

Glucosio Monico delivers glucose directly into the bloodstream via intravenous infusion, providing an immediate rise in plasma glucose, whereas oral tablets must be absorbed through the gastrointestinal tract, which can be slower and is not suitable for patients unable to take oral medication.

Blood glucose levels, serum electrolytes (especially sodium and potassium), and fluid balance should be monitored regularly. Vital signs and signs of fluid overload are also assessed throughout the infusion.

Use in neonates and infants is possible but requires careful dosing and slower infusion rates to avoid metabolic disturbances. Pediatric administration should be guided by a pediatric specialist.

Symptoms may include rash, itching, swelling of the face or throat, difficulty breathing, or anaphylaxis. Any suspected allergic reaction should be reported immediately and managed according to standard emergency protocols.

The solution should be stored at controlled room temperature, protected from light, and kept in its original container until the time of administration. Do not use if the solution appears discolored or contains particles.

Infusion rates depend on the patient’s clinical condition, age, and metabolic needs. Typically, rates are calculated to achieve the desired plasma glucose increase while avoiding rapid spikes; exact rates should be determined by the prescribing clinician.

When given together, Glucosio Monico can counteract insulin‑induced hypoglycemia. Close monitoring of blood glucose is essential, and insulin doses may need adjustment to prevent severe hyper‑ or hypoglycemia.

Renal impairment can affect glucose and electrolyte handling. Dose adjustments, slower infusion rates, and more frequent monitoring of serum electrolytes and fluid status are recommended.

Compatibility depends on the specific solution and concentration. Generally, it can be administered sequentially with most IV fluids, but simultaneous mixing should be verified with compatibility data or pharmacy guidance.

Fluid overload risk is minimized by assessing the patient’s cardiac and renal status, calculating total fluid input, using appropriate infusion rates, and monitoring for signs of pulmonary edema or increased weight.

Published by

GNH India Pharmaceuticals Limited

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Last updated:

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