Product image of Gluscan (Fludeoxyglucose (18f)) supplied by GNH India

Gluscan

Active Ingredient:
Fludeoxyglucose (18f)
Origin:
EU

Gluscan (Fludeoxyglucose (18f))

Gluscan is a radiopharmaceutical product containing the active ingredient fludeoxyglucose (18F) supplied as a sterile solution for injection. It is marketed in the European Union and is available only by prescription. The compound is a fluorine‑18 labeled glucose analog used in positron emission tomography (PET) imaging to assess metabolic activity in various tissues. Gluscan is administered intravenously under controlled conditions and interpreted by qualified physicians.

Manufacturer / TM Owner

Advanced Accelerator Applications Molecular Imaging France S.A.S.

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Indications & Clinical Uses

Gluscan is indicated for diagnostic PET imaging in several clinical specialties.

  • Oncologic PET imaging for tumor detection, staging, and treatment monitoring
  • Cardiac PET imaging to assess myocardial viability and perfusion
  • Neurologic PET imaging for brain metabolism, epilepsy evaluation, and dementia assessment
  • Pediatric oncology imaging when appropriate and dose‑adjusted
  • Research applications such as pharmacokinetic and drug‑development studies

Side Effects

Adverse reactions to Gluscan are generally mild, but rare serious events have been reported.

Common

  • Nausea or mild gastrointestinal discomfort
  • Transient flushing or warmth at the injection site
  • Injection site pain or bruising
  • Mild headache or dizziness

Serious

  • Allergic reactions including anaphylaxis
  • Severe hypoglycemia, especially in diabetic patients
  • Radiation‑related skin erythema or ulceration
  • Acute renal impairment in susceptible individuals

Precautions & Warnings

Use of Gluscan requires careful consideration of patient‑specific factors and procedural safeguards.

  • Verify pregnancy status and defer use unless benefits outweigh risks
  • Ensure adequate patient hydration before and after injection
  • Check fasting blood glucose levels; correct significant hyper‑ or hypoglycemia
  • Apply standard radiation protection measures for staff and family members
  • Avoid use in patients with known severe allergy to radiopharmaceuticals
  • Adjust dosing for pediatric patients according to weight or surface area
  • Review recent exposure to other radiopharmaceuticals or high‑dose imaging studies

Avoid Interactions

Gluscan may interact with other agents that affect glucose metabolism or radiation exposure.

Avoid

  • Concurrent administration of high‑dose iodinated contrast agents within 24 hours
  • Use of another PET radiotracer within 24 hours of Gluscan injection

Use with caution

  • Antidiabetic medications (insulin, sulfonylureas, metformin) that may alter glucose levels
  • Drugs that modify myocardial perfusion (e.g., vasodilators, beta‑blockers)
  • Recent chemotherapy or radiotherapy that could affect tissue uptake
  • Agents that increase serum calcium or phosphate levels
  • Substances influencing renal clearance such as diuretics or nephrotoxic drugs

Frequently Asked Questions

Gluscan contains fludeoxyglucose (18F), a glucose analog that is taken up by metabolically active cells and phosphorylated but not further metabolized, leading to accumulation in tissues that emit positrons detectable by PET scanners.

Gluscan is injected intravenously as a sterile solution. The dose is calculated based on patient weight or body surface area, followed by a waiting period (typically 60 minutes) before PET image acquisition.

Gluscan cardiac PET imaging assesses myocardial viability, perfusion defects, and can help differentiate viable myocardium from scar tissue in patients with coronary artery disease or heart failure.

Gluscan may be used in children when clinically indicated, but dosing is adjusted for weight or surface area, and the benefit‑risk ratio must be carefully evaluated by the ordering physician.

Patients are usually asked to fast for at least 4–6 hours, maintain normal hydration, and have blood glucose measured prior to injection to ensure optimal image quality.

Gluscan is a specific brand of fludeoxyglucose (18F) formulated for injection in the EU market; its purity, sterility, and regulatory specifications may differ from other manufacturers but its imaging properties are comparable.

Common side effects include mild nausea, transient flushing, injection‑site discomfort, and occasional headache. These effects are usually short‑lived and resolve without intervention.

Gluscan is generally contraindicated during pregnancy because the radioactive fluorine‑18 may pose a risk to the fetus; it should only be used if the diagnostic benefit clearly outweighs potential harm.

Gluscan must be stored in a lead‑shielded container at controlled temperature (typically 2–8 °C) and protected from light. Personnel should follow radiation safety protocols during preparation and administration.

Standard precautions include using lead shielding, limiting time of exposure for staff, maintaining distance from the patient after injection, and monitoring radiation dose with appropriate badges.

Imaging usually begins 60 ± 10 minutes after injection, allowing sufficient tracer uptake and clearance of background activity for optimal image contrast.

Combining Gluscan with other radiopharmaceuticals in a single session is generally avoided due to potential interference; if needed, adequate time intervals between agents should be observed as per institutional protocols.

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GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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