Glycerine Enfants Sopreli (Glycerol)

Glycerine Enfants Sopreli is indicated for the temporary relief of constipation in pediatric patients.

• Softens stool by increasing water content in the colon.
• Stimulates bowel movements through osmotic action.
• Can be used when oral laxatives are not tolerated or ineffective.
• Suitable for children who require a rectal route for faster onset.
• May be employed as part of a bowel‑cleansing regimen prior to minor medical procedures.

The most frequently reported effects of glycerol suppositories are related to local irritation and changes in bowel habits.

Common

• Mild rectal burning or stinging sensation.
• Slight cramping or abdominal discomfort.
• Loose stools or mild diarrhea.
• Temporary increase in gas or flatulence.

Serious

• Severe rectal pain or bleeding.
• Persistent diarrhea leading to dehydration.
• Signs of allergic reaction such as rash, itching, or swelling.
• Unexpected abdominal pain that does not resolve.

When using Glycerine Enfants Sopreli, certain precautions should be observed to ensure safe and effective use.

• Do not use for longer than a few days without medical advice.
• Avoid use in children with known hypersensitivity to glycerol or any excipients.
• Consult a healthcare professional before use in infants younger than 2 years.
• Ensure proper insertion technique to minimize mucosal injury.
• Monitor for signs of dehydration or electrolyte imbalance, especially with repeated doses.
• Keep the product out of reach of children to prevent accidental ingestion.

Glycerol suppositories have a low potential for systemic drug interactions, but certain substances may affect their safety or efficacy.

Avoid

• Concurrent use of strong stimulant laxatives, which may increase the risk of electrolyte disturbances.
• Use with rectal irritants such as enemas containing harsh chemicals.
• Use with anticoagulant suppositories, as local irritation could increase bleeding risk.

Use with caution

• Combination with oral osmotic laxatives (e.g., polyethylene glycol) may lead to excessive fluid loss.
• Administration together with medications that cause diarrhea, such as certain antibiotics, should be monitored.
• Use with antidiarrheal agents (e.g., loperamide) may reduce the intended laxative effect.
• Co‑administration with drugs that require consistent intestinal absorption may be affected by altered transit time.