Product image of Glyceroltrinitrat Carinopharm (Glyceryl Trinitrate) supplied by GNH India

Glyceroltrinitrat Carinopharm

Active Ingredient:
Glyceryl Trinitrate
Origin:
EU

Glyceroltrinitrat Carinopharm (Glyceryl Trinitrate)

Glyceroltrinitrat Carinopharm contains the active ingredient glyceryl trinitrate in an intravenous formulation. It is a prescription‑only organic nitrate marketed in the European Union. The product delivers nitric‑oxide mediated vasodilation to reduce myocardial oxygen demand. While the exact strength is not specified, the preparation is used by healthcare professionals in acute care settings.

Manufacturer / TM Owner

Carinopharm Gmbh

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Indications & Clinical Uses

Glyceroltrinitrat Carinopharm is indicated for rapid relief of several acute cardiovascular conditions where prompt vasodilation is required.

  • Acute angina pectoris, including episodes unresponsive to oral nitrates.
  • Acute decompensated heart failure with pulmonary congestion.
  • Hypertensive emergencies or severe hypertension requiring immediate reduction.
  • Controlled hypotension during surgical procedures.

Side Effects

Side effects of intravenous glyceryl trinitrate reflect its vasodilatory action and may vary in frequency.

Common

  • Headache, often transient.
  • Flushing or warmth sensation.
  • Dizziness or light‑headedness.
  • Mild to moderate hypotension.
  • Reflex tachycardia.

Serious

  • Severe hypotension leading to syncope.
  • Myocardial ischemia or infarction.
  • Life‑threatening arrhythmias.
  • Methemoglobinemia (rare).

Precautions & Warnings

When using Glyceroltrinitrat Carinopharm, clinicians should observe several precautions to minimise risk.

  • Avoid in patients with known hypersensitivity to organic nitrates.
  • Contraindicated in severe anemia or increased intracranial pressure.
  • Use cautiously in patients taking phosphodiesterase‑5 inhibitors due to risk of profound hypotension.
  • Monitor blood pressure and heart rate continuously during infusion.
  • Adjust dose in elderly or patients with hepatic impairment.
  • Ensure adequate fluid status to prevent excessive blood pressure drop.

Avoid Interactions

Glyceroltrinitrat Carinopharm can interact with other medications that affect vascular tone or cardiac function.

Avoid

  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil, tadalafil).
  • Other nitrate preparations or nitrites.
  • Strong antihypertensive agents (e.g., ACE inhibitors, ARBs) given concurrently.

Use with caution

  • Beta‑blockers, which may mask tachycardia.
  • Diuretics, which can enhance hypotensive effect.
  • General anesthetics, especially those causing vasodilation.

Frequently Asked Questions

Glyceryl trinitrate releases nitric oxide, which relaxes smooth muscle in veins and arteries, producing vasodilation and reducing myocardial oxygen demand.

The product is supplied as an intravenous solution and is administered by a healthcare professional under continuous monitoring.

It is commonly used for acute angina pectoris, acute decompensated heart failure, and hypertensive emergencies.

Concurrent use with phosphodiesterase‑5 inhibitors such as sildenafil is contraindicated because it can cause severe hypotension.

The most frequent side effects include headache, flushing, dizziness, mild hypotension, and reflex tachycardia.

The safety of this product during pregnancy has not been established; it should be used only if the potential benefit justifies the potential risk.

Blood pressure, heart rate, and electrocardiogram should be monitored continuously to detect hypotension or arrhythmias early.

Yes, elderly patients may be more sensitive to vasodilation and often require a lower initial infusion rate with careful titration.

If severe hypotension develops, the infusion should be stopped immediately and the patient positioned supine with legs elevated while supportive measures are provided.

The product should be stored at controlled room temperature, protected from light, and kept in the original container until use.

Concurrent administration of other nitrate or nitrite preparations is avoided because it can lead to additive hypotensive effects.

The ATC code for glyceryl trinitrate is C01DA02, classifying it as a cardiac preparation, vasodilator.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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