Product image of Glycopyrrolate And Neostigmine Metilsulfate Mercury Pharmaceuticals Ltd, (Glycopyrronium Bromide, Neostigmine Methylsulfate) supplied by GNH India

Glycopyrrolate And Neostigmine Metilsulfate Mercury Pharmaceuticals Ltd,

Active Ingredient:
Glycopyrronium Bromide, Neostigmine Methylsulfate
Origin:
EU

Glycopyrrolate And Neostigmine Metilsulfate Mercury Pharmaceuticals Ltd, (Glycopyrronium Bromide, Neostigmine Methylsulfate)

Glycopyrrolate And Neostigmine Metilsulfate by Mercury Pharmaceuticals Ltd contains the active ingredients glycopyrronium bromide and neostigmine methylsulfate and is supplied as an injectable solution for intravenous use. It is a prescription‑only medication classified as an anticholinergic and acetylcholinesterase inhibitor, indicated for reversal of non‑depolarizing neuromuscular blockade and related peri‑operative applications.

Manufacturer / TM Owner

Mercury Pharmaceuticals Ltd.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Glycopyrrolate and neostigmine is used in the peri‑operative setting to facilitate safe emergence from anesthesia. It is administered intravenously after surgery when reversal of neuromuscular blockade is required.

  • Reversal of non‑depolarizing neuromuscular blockade
  • Prevention of bradycardia during reversal of neuromuscular blockade
  • Reduction of salivary, bronchial and gastric secretions
  • Adjunct to anesthetic management in patients at risk of excessive secretions
  • Support of spontaneous respiration after muscle relaxant use

Side Effects

Side effects may vary in frequency and severity. Common reactions are usually mild and transient, while serious events are rare but require prompt medical attention.

Common

  • Dry mouth
  • Facial flushing
  • Transient tachycardia
  • Nausea or mild vomiting
  • Mild hypotension
  • Headache

Serious

  • Severe bradycardia or arrhythmias
  • Bronchospasm or respiratory distress
  • Anaphylactic reaction
  • Persistent hypertension
  • Prolonged neuromuscular blockade
  • Seizure activity

Precautions & Warnings

Clinicians should assess patient-specific factors before administering this combination. Proper monitoring and dose adjustment are essential to minimize risks.

  • Evaluate cardiac history, especially for bradyarrhythmias
  • Use caution in patients with asthma or chronic obstructive pulmonary disease
  • Adjust dose in renal or hepatic impairment
  • Monitor neuromuscular function closely during reversal
  • Avoid use in patients with known hypersensitivity to either component
  • Ensure appropriate ventilation support is available during administration

Avoid Interactions

Potential drug interactions may affect the efficacy or safety of glycopyrrolate and neostigmine. Some combinations should be avoided, while others require careful monitoring.

Avoid

  • Other anticholinergic agents that may exacerbate dry mouth or tachycardia
  • Potent cholinesterase inhibitors that could potentiate neostigmine effects
  • Beta‑blockers that may mask tachycardia

Use with caution

  • Cardiovascular drugs such as digoxin or calcium channel blockers
  • Anesthetic agents that depress respiratory drive
  • Drugs that prolong the QT interval
  • Medications affecting renal clearance (e.g., aminoglycosides)

Frequently Asked Questions

The combination is used to reverse the effects of non‑depolarizing neuromuscular blocking agents after surgery and to reduce excess secretions.

It is given as an intravenous injection, typically as a single dose administered by a qualified healthcare professional.

Caution is advised because neostigmine can increase bronchial secretions; clinicians should assess respiratory status before use.

Patients should be monitored for heart rate, blood pressure, neuromuscular function, and signs of respiratory distress.

The pregnancy safety category is not established; it should be used only if the potential benefit justifies the potential risk to the fetus.

Common side effects include dry mouth, facial flushing, transient tachycardia, mild nausea, mild hypotension, and headache.

Serious reactions include severe bradycardia or arrhythmias, bronchospasm, anaphylaxis, prolonged neuromuscular blockade, seizures, and persistent hypertension.

Concurrent use of additional anticholinergics is generally avoided because it may increase the risk of dry mouth and tachycardia.

Neostigmine inhibits acetylcholinesterase, raising acetylcholine levels at the neuromuscular junction, which competes with the blocking agent and restores muscle tone.

Glycopyrrolate acts as a competitive muscarinic antagonist, reducing salivary, bronchial, and gastric secretions and helping to prevent bradycardia during reversal.

Dose adjustment may be necessary in renal impairment because neostigmine is primarily excreted by the kidneys; clinicians should evaluate renal function before dosing.

No, glycopyrrolate and neostigmine is a prescription‑only medication and must be administered under medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Glycopyrronium Bromide, Neostigmine Methylsulfate

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT