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Glycopyrronium Bromide Accord Healthcare

Active Ingredient:
Glycopyrronium Bromide
Origin:
EU

Glycopyrronium Bromide Accord Healthcare (Glycopyrronium Bromide)

Glycopyrronium Bromide Accord Healthcare is a prescription medication that contains the active ingredient glycopyrronium bromide. It is supplied in an injectable form for intramuscular or intravenous administration, with the specific strength provided by Accord Healthcare for use in the European market. The product belongs to the anticholinergic (muscarinic antagonist) class and is used as a bronchodilator in respiratory therapy.

Manufacturer / TM Owner

Accord Healthcare Limited

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Indications & Clinical Uses

Glycopyrronium Bromide is indicated for the management of chronic obstructive pulmonary disease (COPD) and related airway obstruction. It is employed as a maintenance therapy to improve breathing and reduce symptoms.

  • Long‑term treatment of COPD to decrease bronchospasm
  • Adjunct therapy for patients with persistent airflow limitation
  • Helps improve lung function and exercise tolerance
  • May be used when other bronchodilators are insufficient
  • Supports reduction of mucus secretion in the airways

Side Effects

Side effects of glycopyrronium bromide vary in frequency and severity. Common reactions are usually mild, while serious events are less frequent but require medical attention.

Common

  • Dry mouth
  • Constipation
  • Urinary retention
  • Blurred vision
  • Tachycardia
  • Headache

Serious

  • Severe allergic reaction (rash, swelling, difficulty breathing)
  • Acute angle‑closure glaucoma
  • Cardiac arrhythmias
  • Paradoxical bronchospasm
  • Persistent urinary retention requiring intervention

Precautions & Warnings

Before using glycopyrronium bromide, certain health considerations should be reviewed to ensure safe use.

  • Assess for a history of urinary retention, prostate enlargement, or bladder outlet obstruction
  • Use cautiously in patients with narrow‑angle glaucoma or other ocular disorders
  • Monitor cardiovascular status in individuals with arrhythmias or heart disease
  • Consider dose adjustment in hepatic impairment
  • Evaluate risks versus benefits in elderly patients
  • Pregnancy and lactation safety data are limited; discuss with a healthcare professional

Avoid Interactions

Glycopyrronium bromide may interact with other medicines, affecting its efficacy or safety profile.

Avoid

  • Concurrent use of other anticholinergic agents that may increase anticholinergic burden
  • Drugs known to prolong the QT interval when combined with glycopyrronium bromide

Use with caution

  • Beta‑agonists or other bronchodilators, as additive bronchodilation may occur
  • Cholinesterase inhibitors used for myasthenia gravis or Alzheimer’s disease
  • Medications that affect urinary retention, such as antihistamines or tricyclic antidepressants
  • Cardiovascular drugs that influence heart rate or rhythm

Frequently Asked Questions

Glycopyrronium bromide works by competitively blocking muscarinic acetylcholine receptors in the airway smooth muscle, leading to relaxation of the bronchi and reduced mucus secretion.

The medication is supplied as an injectable solution and can be given either intramuscularly or intravenously under the supervision of a healthcare professional.

No, glycopyrronium bromide is intended for maintenance therapy of COPD and is not typically used as a short‑acting rescue medication.

While it is primarily approved for COPD, a healthcare provider may consider off‑label use in asthma after evaluating the individual’s clinical situation.

Common side effects include dry mouth, constipation, urinary retention, blurred vision, tachycardia, and headache.

Medical attention is needed if the patient experiences signs of a severe allergic reaction, acute angle‑closure glaucoma, significant arrhythmias, or persistent urinary retention.

Safety data for use during pregnancy are limited; the medication should only be used if the potential benefit justifies the potential risk to the fetus.

Elderly patients may be more susceptible to anticholinergic side effects such as urinary retention and constipation, so careful monitoring is advised.

Yes, using glycopyrronium bromide together with beta‑agonist bronchodilators may increase bronchodilation; clinicians often monitor lung function when both are prescribed.

Store the injectable solution at controlled room temperature, away from light and moisture, and keep it out of reach of children.

The ATC classification for glycopyrronium bromide is R03BB02, indicating it is a bronchodilator in the anticholinergic subgroup.

Glycopyrronium bromide is not classified as a controlled substance; it is available by prescription only.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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