Product image of Glycopyrronium Bromide Mercury Pharmaceuticals Ltd, (Glycopyrronium Bromide) supplied by GNH India

Glycopyrronium Bromide Mercury Pharmaceuticals Ltd,

Active Ingredient:
Glycopyrronium Bromide
Origin:
EU

Glycopyrronium Bromide Mercury Pharmaceuticals Ltd, (Glycopyrronium Bromide)

Glycopyrrium Bromide Mercury Pharmaceuticals Ltd is a prescription‑only antimuscarinic medication supplied in injectable form. The product contains the active ingredient glycopyrronium bromide and is marketed in the European Union. It is administered by intramuscular or intravenous injection and belongs to the anticholinergic drug class, acting as a competitive antagonist at muscarinic acetylcholine receptors. Its pharmacological profile includes reduction of glandular secretions and bronchodilation, making it useful in operative settings.

Manufacturer / TM Owner

Mercury Pharmaceuticals Ltd.

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Indications & Clinical Uses

Glycopyrronium bromide is employed in several clinical situations where reduction of secretions or bronchodilation is desired.

  • Management of excessive salivary, respiratory or gastrointestinal secretions during surgery or intensive care.
  • Adjunct therapy for chronic obstructive pulmonary disease (COPD) to improve airflow.
  • Pre‑operative preparation to reduce airway secretions and facilitate intubation.
  • Treatment of hyperhidrosis (excessive sweating) when administered systemically.
  • Control of bronchospasm in acute severe asthma as an adjunct.

Side Effects

The safety profile of injectable glycopyrronium bromide includes both frequent, mild reactions and rare, serious events.

Common

  • Dry mouth or reduced salivation.
  • Facial flushing or warmth.
  • Increased heart rate (tachycardia).
  • Urinary retention or difficulty voiding.

Serious

  • Severe allergic reaction (anaphylaxis).
  • Cardiac arrhythmias or significant hypotension.
  • Acute angle‑closure glaucoma.

Precautions & Warnings

Healthcare professionals should consider several precautionary measures before prescribing injectable glycopyrronium bromide.

  • Assess for known hypersensitivity to glycopyrronium or related anticholinergics.
  • Use cautiously in patients with glaucoma, especially narrow‑angle type.
  • Monitor cardiac function in individuals with arrhythmias or coronary disease.
  • Avoid in patients with urinary retention, prostatic hypertrophy, or gastrointestinal obstruction.
  • Adjust dose in renal impairment, as the drug is primarily excreted unchanged.
  • Consider pregnancy status; safety data are limited.

Avoid Interactions

Glycopyrronium bromide may interact with other medications, altering its efficacy or safety.

Avoid

  • Concurrent use with other anticholinergic agents (e.g., atropine, scopolamine) may increase anticholinergic burden.
  • Combination with potent CYP3A4 inhibitors is not typical, but caution is advised when drugs affect renal clearance.

Use with caution

  • Beta‑agonists or other bronchodilators may have additive cardiovascular effects.
  • Medications that prolong the QT interval should be used cautiously due to possible tachycardia.
  • Anesthetic agents that depress respiration may require monitoring when glycopyrronium is used.

Frequently Asked Questions

Glycopyrronium bromide is an antimuscarinic (muscarinic antagonist) that competitively blocks muscarinic acetylcholine receptors, leading to reduced glandular secretions and bronchodilation.

It is commonly used to control excessive secretions during surgery or intensive care, as an adjunct in COPD management, for pre‑operative airway preparation, and to treat hyperhidrosis or acute bronchospasm.

By blocking muscarinic receptors on salivary and respiratory glands, the drug decreases the release of mucus and other secretions.

Yes, it may be used as an adjunct therapy in COPD to promote bronchodilation and reduce mucus production, improving airflow.

Common side effects include dry mouth, facial flushing, tachycardia, and urinary retention.

Monitoring is advised for signs of anaphylaxis, cardiac arrhythmias, significant hypotension, or acute angle‑closure glaucoma, especially after the first dose.

Contraindications include known hypersensitivity to the drug or other anticholinergics, and caution is required in patients with narrow‑angle glaucoma or uncontrolled urinary obstruction.

The medication is supplied for intramuscular or intravenous injection and should be given by a qualified healthcare professional following aseptic technique and appropriate dosing guidelines.

Other anticholinergic agents should be avoided because they can increase anticholinergic side effects.

Safety data for pregnancy and lactation are limited; the drug should be used only if the potential benefit justifies the potential risk to the fetus or infant.

Since the drug is primarily excreted unchanged by the kidneys, dose adjustment or increased monitoring may be necessary in patients with significant renal dysfunction.

The injection should be stopped immediately, and appropriate emergency measures such as administration of epinephrine, antihistamines, and supportive care should be initiated.

Published by

GNH India Pharmaceuticals Limited

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Last updated:

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