Product image of Glycopyrronium Martindale (Glycopyrronium Bromide) supplied by GNH India

Glycopyrronium Martindale

Active Ingredient:
Glycopyrronium Bromide
Origin:
EU

Glycopyrronium Martindale (Glycopyrronium Bromide)

Glycopyrronium Martindale is a product containing active ingredient glycopyrronium bromide. It is supplied as an injectable solution for intramuscular and intravenous use. Marketed in the European Union and available by prescription only, this anticholinergic (muscarinic antagonist) belongs to the antimuscarinic agent class and carries ATC code R03BB04. It works by competitively blocking muscarinic acetylcholine receptors to reduce parasympathetic activity. It is employed in patients requiring airway management during surgery.

Manufacturer / TM Owner

Ethypharm

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Indications & Clinical Uses

Glycopyrronium Martindale is administered in clinical settings where reduction of muscarinic activity is desired.

  • As an adjunct to anesthesia to decrease oral, respiratory, and gastric secretions.
  • To manage excessive sweating (hyperhidrosis) in refractory cases.
  • For treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD) when other therapies are insufficient.
  • To facilitate endotracheal intubation by reducing airway secretions.
  • In certain cardiac surgeries to control vagal tone.

Side Effects

Side effects of Glycopyrronium Martindale reflect its anticholinergic activity and vary in frequency.

Common

  • Dry mouth.
  • Reduced sweating.
  • Blurred vision.
  • Constipation.
  • Urinary retention.

Serious

  • Tachycardia.
  • Severe hypotension.
  • Acute angle‑closure glaucoma.
  • Allergic reactions such as rash or anaphylaxis.
  • Cardiac arrhythmias.

Precautions & Warnings

Before using Glycopyrronium Martindale, clinicians should consider several precautionary factors to ensure safe administration.

  • Assess for known hypersensitivity to glycopyrronium or similar anticholinergics.
  • Use caution in patients with glaucoma, especially narrow‑angle type.
  • Monitor cardiac function in individuals with pre‑existing arrhythmias or coronary disease.
  • Evaluate renal or hepatic impairment as drug elimination may be altered.
  • Avoid in patients with severe urinary retention or gastrointestinal obstruction.
  • Consider dose adjustment in the elderly.

Avoid Interactions

Glycopyrronium Martindale can interact with other medications that influence cholinergic pathways or cardiovascular function.

Avoid

  • Other anticholinergic agents (e.g., atropine, scopolamine) due to additive effects.
  • Sympathomimetic drugs that may exacerbate tachycardia.
  • Monoamine oxidase inhibitors when combined with certain bronchodilators.

Use with caution

  • Beta‑agonist bronchodilators (e.g., albuterol) as combined effect on airway tone may occur.
  • Drugs that prolong the QT interval.
  • Anesthetic agents that depress cardiac output.

Frequently Asked Questions

Glycopyrronium Martindale works by competitively antagonizing muscarinic acetylcholine receptors, which reduces parasympathetic nervous system activity.

The product is formulated for intramuscular and intravenous injection.

No, Glycopyrronium Martindale is a prescription‑only medication in the European Union.

It is commonly used to reduce secretions during anesthesia, manage hyperhidrosis, treat bronchospasm in COPD, facilitate endotracheal intubation, and control vagal tone in certain cardiac procedures.

Common side effects include dry mouth, reduced sweating, blurred vision, constipation, and urinary retention.

Serious reactions can include tachycardia, severe hypotension, acute angle‑closure glaucoma, allergic responses such as rash or anaphylaxis, and cardiac arrhythmias.

Caution is advised, especially in patients with narrow‑angle glaucoma, because anticholinergic effects can increase intra‑ocular pressure.

Elderly patients may be more susceptible to anticholinergic side effects and may require dose adjustments or closer monitoring.

Concurrent use with other anticholinergics should be avoided due to the risk of additive anticholinergic effects.

Avoid combining with other anticholinergics, sympathomimetics that may cause tachycardia, and MAO inhibitors with certain bronchodilators. Use caution with beta‑agonist bronchodilators, QT‑prolonging agents, and anesthetics that depress cardiac output.

Renal or hepatic dysfunction may affect drug elimination, so clinicians should evaluate organ function and adjust therapy as needed.

The ATC code for Glycopyrronium bromide is R03BB04.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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