Product image of Glycopyrroniumbromid Martindale (Glycopyrronium Bromide) supplied by GNH India

Glycopyrroniumbromid Martindale

Active Ingredient:
Glycopyrronium Bromide
Origin:
EU

Glycopyrroniumbromid Martindale (Glycopyrronium Bromide)

Glycopyrroniumbromid Martindale, containing the active ingredient glycopyrronium bromide, is an injectable anticholinergic medication supplied in a sterile solution for intramuscular or intravenous use. It belongs to the muscarinic antagonist class and is marketed in the European Union as a prescription‑only product. The formulation is designed to reduce secretions and modulate autonomic activity during specific medical procedures. It is typically stored under controlled temperature conditions and administered by qualified healthcare professionals.

Manufacturer / TM Owner

Ethypharm

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Indications & Clinical Uses

Glycopyrroniumbromid Martindale is employed in clinical settings to manage excessive secretions and certain cardiac rhythm disturbances. Its anticholinergic action makes it useful for several peri‑operative and therapeutic purposes.

  • Preoperative reduction of salivary, respiratory and other secretions.
  • Control of intra‑operative bronchial secretions during anesthesia.
  • Treatment of bradyarrhythmias such as sinus bradycardia.
  • Adjunct therapy for refractory hyperhidrosis (off‑label use).
  • Facilitation of diagnostic procedures that require minimal secretions.

Side Effects

Glycopyrroniumbromid Martindale may cause a range of anticholinergic‑related effects, varying from mild and transient to rare but serious reactions. Patients should be monitored for these events.

Common

  • Dry mouth (xerostomia).
  • Reduced sweating (anhidrosis).
  • Blurred vision.
  • Constipation.
  • Tachycardia.

Serious

  • Severe hypotension.
  • Acute urinary retention.
  • Allergic reactions such as rash or anaphylaxis.

Precautions & Warnings

Glycopyrroniumbromid Martindale requires careful consideration in patients with specific medical conditions or concurrent therapies. The following precautions help minimize risk.

  • Use cautiously in patients with glaucoma or other ocular disorders.
  • Avoid in individuals with known hypersensitivity to glycopyrronium bromide or excipients.
  • Monitor heart rate and blood pressure in patients with cardiac disease.
  • Adjust dose or observe closely in renal or hepatic impairment.
  • Consider alternative agents in pregnant or breastfeeding women, as safety data are limited.

Avoid Interactions

Glycopyrroniumbromid Martindale can interact with other medications that affect cholinergic pathways or cardiovascular function. Awareness of these interactions supports safe co‑administration.

Avoid

  • Other anticholinergic drugs (e.g., atropine, scopolamine) that may potentiate antimuscarinic effects.
  • Sympathomimetic agents that increase heart rate (e.g., epinephrine) due to additive tachycardia.
  • Drugs that prolong QT interval, increasing risk of arrhythmias.

Use with caution

  • Anesthetic agents that depress respiratory function.
  • Neuromuscular blocking agents, as glycopyrronium may affect muscle relaxation.

Frequently Asked Questions

It is an injectable anticholinergic drug that acts as a muscarinic receptor antagonist to reduce secretions and modulate autonomic activity.

The product is formulated for intramuscular and intravenous injection.

Yes, it is sometimes used off‑label for the management of hyperhidrosis, although this is not an approved indication.

The ATC code is A03BA02, placing it in the group of drugs for functional gastrointestinal disorders, anticholinergics.

No, it is a prescription‑only medication in the European Union.

Clinicians should monitor heart rate, blood pressure, respiratory status, and for signs of anticholinergic side effects such as dry mouth or urinary retention.

It should be avoided in patients with known hypersensitivity to glycopyrronium bromide or its excipients and used with caution in glaucoma, severe cardiac disease, or uncontrolled hypertension.

Both are antimuscarinic agents, but glycopyrronium bromide has a quaternary ammonium structure, limiting its ability to cross the blood‑brain barrier and reducing central nervous system effects.

It can be used alongside many anesthetics, but caution is advised when combined with agents that depress respiration or interact with neuromuscular blockers.

The solution should be stored at controlled room temperature, protected from light, and kept out of reach of children.

Pregnancy safety data are limited; therefore, it is generally avoided or used only when the potential benefit justifies the potential risk.

The most frequently reported adverse effects include dry mouth, reduced sweating, blurred vision, constipation, and a mild increase in heart rate.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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