Product image of Glykopyrroniumbromidi Accord (Glycopyrronium Bromide) supplied by GNH India

Glykopyrroniumbromidi Accord

Active Ingredient:
Glycopyrronium Bromide
Origin:
EU

Glykopyrroniumbromidi Accord (Glycopyrronium Bromide)

Glykopyrroniumbromidi Accord contains the anticholinergic agent glycopyrronium bromide in an injectable form. It is a prescription‑only product marketed in the European Union and is used as a bronchodilator and antisecretory agent. The medication works by competitively blocking muscarinic acetylcholine receptors, which reduces secretions and relaxes airway smooth muscle.

Manufacturer / TM Owner

Accord Healthcare B.V.

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Indications & Clinical Uses

Glykopyrroniumbromidi Accord is indicated for several clinical situations where reduction of secretions or bronchodilation is desired.

  • Pre‑operative reduction of salivary and respiratory secretions to improve airway management.
  • Adjunct therapy in chronic obstructive pulmonary disease (COPD) to aid bronchodilation.
  • Treatment of hyperhidrosis when other options are insufficient.
  • Management of excessive bronchial secretions in certain respiratory conditions.
  • Supportive care in anesthesia to control airway secretions.

Side Effects

Side effects of glycopyrrium bromide may vary in frequency and severity.

Common

  • Dry mouth (xerostomia).
  • Throat irritation.
  • Nasal dryness.
  • Blurred vision.
  • Constipation.
  • Urinary retention.

Serious

  • Severe allergic reaction (anaphylaxis).
  • Acute angle‑closure glaucoma.
  • Significant tachycardia.
  • Cardiac arrhythmias.
  • Marked hypotension.
  • Persistent urinary retention requiring catheterisation.

Precautions & Warnings

Before using Glykopyrroniumbromidi Accord, clinicians should consider several safety factors.

  • Assess for a history of glaucoma, especially narrow‑angle type.
  • Evaluate cardiac function in patients with known arrhythmias or tachycardia.
  • Use caution in individuals with urinary retention or prostate enlargement.
  • Monitor for signs of hypersensitivity during and after administration.
  • Adjust dose or avoid use in patients with severe gastrointestinal motility disorders.
  • Consider renal or hepatic impairment when determining dosing frequency.

Avoid Interactions

Glycopyrronium bromide may interact with other medications, requiring careful management.

Avoid

  • Other anticholinergic agents (e.g., atropine, scopolamine) that may increase anticholinergic burden.
  • Drugs that prolong the QT interval, as additive cardiac effects are possible.

Use with caution

  • Beta‑agonists or other bronchodilators, monitoring for excessive cardiovascular stimulation.
  • Medications that lower intra‑ocular pressure, due to potential glaucoma risk.
  • Opioids, as anticholinergic effects may mask constipation.
  • Diuretics, because of possible additive effects on electrolyte balance.

Frequently Asked Questions

Glycopyrronium bromide competitively blocks muscarinic acetylcholine receptors, reducing glandular secretions and causing relaxation of airway smooth muscle, which leads to bronchodilation.

It is not typically first‑line for asthma; its primary indications are COPD, pre‑operative secretion control, and hyperhidrosis. Use in asthma should follow specialist guidance.

The product is supplied for intramuscular or intravenous injection, administered by a healthcare professional according to the prescribed regimen.

Common adverse effects include dry mouth, throat irritation, nasal dryness, blurred vision, constipation, and urinary retention.

Avoid use in patients with known hypersensitivity to glycopyrronium bromide, severe narrow‑angle glaucoma, or when combined with other strong anticholinergic drugs without medical supervision.

Pregnancy safety data are limited; the product should only be used if the potential benefit justifies the potential risk to the fetus, after consulting a physician.

Yes, glycopyrronium bromide can cause tachycardia or arrhythmias, especially in patients with pre‑existing cardiac conditions; monitoring is recommended.

Clinicians should monitor for signs of allergic reaction, changes in intra‑ocular pressure, urinary output, and cardiovascular status during and after dosing.

No specific dietary restrictions are required, but patients should stay hydrated and report any severe constipation.

Both are anticholinergics, but glycopyrronium bromide has a quaternary ammonium structure, limiting its ability to cross the blood‑brain barrier, resulting in fewer central nervous system effects compared with atropine.

Patients should inform their healthcare provider; saliva substitutes or sugar‑free lozenges may be recommended, and dose adjustment may be considered.

No, it is a prescription‑only medication and must be prescribed by a qualified healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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