Product image of Glypvilo (Vildagliptin) supplied by GNH India

Glypvilo

Active Ingredient:
Vildagliptin
Origin:
EU

Glypvilo (Vildagliptin)

Glypvilo is a prescription medication that contains the active ingredient vildagliptin, supplied as oral tablets (strength not specified). It belongs to the dipeptidyl peptidase‑4 (DPP‑4) inhibitor class and is marketed in the European Union for the management of type 2 diabetes mellitus.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Glypvilo is indicated for the treatment of adults with type 2 diabetes mellitus, typically as part of a comprehensive diabetes management plan. It may be used alone or in combination with other antidiabetic agents.

  • Improves glycemic control when added to diet and exercise.
  • Can be combined with metformin for enhanced effect.
  • May be used with sulfonylureas in patients not achieving target glucose levels.
  • Suitable for patients who require an oral DPP‑4 inhibitor.
  • Often prescribed when other oral agents are insufficient.

Side Effects

Side effects of Glypvilo vary in frequency and severity. Patients should be aware of both common and serious reactions.

Common

  • Upper respiratory tract infection
  • Headache
  • Dizziness
  • Nausea
  • Diarrhea
  • Skin rash

Serious

  • Severe allergic reactions (anaphylaxis, angioedema)
  • Pancreatitis symptoms (persistent abdominal pain)
  • Hepatotoxicity (elevated liver enzymes)
  • Severe hypoglycemia when combined with insulin or sulfonylureas

Precautions & Warnings

Before starting Glypvilo, certain health considerations should be reviewed to ensure safe use.

  • Assess renal function; dose adjustment may be needed in impairment.
  • Monitor liver enzymes periodically during therapy.
  • Use caution in patients with a history of pancreatitis.
  • Evaluate for potential hypersensitivity reactions.
  • Educate patients on recognizing signs of hypoglycemia, especially when used with insulin or sulfonylureas.
  • Discuss pregnancy and lactation status with a healthcare professional.

Avoid Interactions

Glypvilo can interact with several drug classes, requiring attention to avoid adverse effects.

Avoid

  • Strong CYP3A4 inhibitors (e.g., ketoconazole) that may increase vildagliptin exposure.
  • Concurrent use with other DPP‑4 inhibitors.

Use with caution

  • Insulin or sulfonylureas (risk of hypoglycemia).
  • Diuretics that may affect renal clearance.
  • NSAIDs that could impact renal function.
  • Rifampin (possible reduction in efficacy).

Frequently Asked Questions

Glypvilo inhibits the dipeptidyl peptidase‑4 (DPP‑4) enzyme, which increases endogenous incretin hormones (GLP‑1 and GIP). This enhances glucose‑dependent insulin secretion and reduces glucagon release, helping to lower blood glucose levels.

Glypvilo may be prescribed as initial therapy in patients who cannot tolerate metformin or when a DPP‑4 inhibitor is preferred, but treatment decisions should be individualized by a healthcare professional.

Yes, renal function should be evaluated before initiating Glypvilo, and dose adjustments may be necessary for patients with moderate to severe renal impairment.

Common adverse effects include upper respiratory tract infections, headache, dizziness, nausea, diarrhea, and mild skin rash.

Serious reactions can include severe allergic responses (anaphylaxis, angioedema), signs of pancreatitis (persistent abdominal pain), liver enzyme elevations, and severe hypoglycemia when combined with insulin or sulfonylureas.

Glypvilo can be taken with or without food; however, consistent administration with respect to meals may help maintain stable drug levels.

Yes, Glypvilo is often prescribed in combination with metformin to improve glycemic control when metformin alone does not achieve target glucose levels.

Regular monitoring of blood glucose, renal function, and liver enzymes is recommended, along with periodic assessment for signs of pancreatitis or hypersensitivity.

The safety of Glypvilo during pregnancy and lactation has not been fully established; it should only be used if the potential benefit justifies the potential risk, under medical supervision.

If a dose is missed, take it as soon as remembered unless it is near the time of the next scheduled dose. Do not double the dose; continue with the regular dosing schedule.

There are no specific dietary restrictions, but patients should maintain a balanced diet and avoid excessive alcohol, which can affect blood glucose control.

Glypvilo contains vildagliptin, which has a similar efficacy profile to other DPP‑4 inhibitors but may differ in dosing frequency, pharmacokinetics, and individual patient tolerability.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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