Product image of Gonasi (Human Chorionic Gonadotropin) supplied by GNH India

Gonasi

Active Ingredient:
Human Chorionic Gonadotropin
Origin:
EU

Gonasi (Human Chorionic Gonadotropin)

Gonasi is a prescription medication that contains the hormone human chorionic gonadotropin (hCG) as its active ingredient. It is supplied as an injectable solution for intramuscular or subcutaneous use, with the specific strength defined by the prescribing information. Marketed in the European Union, Gonasi belongs to the gonadotropin hormone class and is intended for use under the supervision of a qualified healthcare professional.

Manufacturer / TM Owner

Ibsa Farmaceutici Italia

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Indications & Clinical Uses

Gonasi is employed in several reproductive‑health settings where stimulation of luteinizing hormone receptors is required.

  • Induction of ovulation in women with anovulatory infertility.
  • Luteal phase support during assisted reproductive technology cycles.
  • Treatment of cryptorchidism in male infants.
  • Stimulation of testosterone production in men with hypogonadism.
  • Adjunct therapy in certain cases of delayed puberty.

Side Effects

Side effects of Gonasi vary in frequency and severity.

Common

  • Injection site pain or bruising.
  • Headache.
  • Nausea or mild abdominal discomfort.
  • Breast tenderness or swelling.
  • Mild fluid retention.

Serious

  • Ovarian hyperstimulation syndrome (OHSS).
  • Allergic reactions such as rash, itching, or anaphylaxis.
  • Thromboembolic events.
  • Severe abdominal pain indicating ovarian torsion.
  • Rapid weight gain due to fluid overload.

Precautions & Warnings

Before initiating Gonasi therapy, several safety considerations should be reviewed.

  • Confirm pregnancy status; avoid use in confirmed pregnancy unless specifically indicated.
  • Assess for ovarian cysts or enlarged ovaries prior to dosing.
  • Monitor patients with a history of thromboembolic disease closely.
  • Use caution in individuals with uncontrolled hypertension or cardiovascular disease.
  • Evaluate for hypersensitivity to hCG or any formulation components.
  • Adjust dosing in patients with severe renal or hepatic impairment as directed by a physician.

Avoid Interactions

Gonasi may interact with other medications or substances that affect hormonal balance or coagulation.

Avoid

  • Concurrent use of high‑dose estrogen therapy, which may increase the risk of ovarian hyperstimulation.
  • Anticoagulant agents without close monitoring, due to potential additive thrombotic risk.

Use with caution

  • Gonadotropin‑releasing hormone (GnRH) agonists or antagonists.
  • Steroid hormones such as testosterone or anabolic steroids.
  • Medications that alter fluid balance, e.g., diuretics.
  • Drugs that affect liver enzymes (CYP450) which could modify hCG metabolism.

Frequently Asked Questions

Gonasi contains human chorionic gonadotropin (hCG) as its sole active ingredient.

Gonasi is supplied as an injectable solution and is given either intramuscularly or subcutaneously according to the prescribing instructions.

Gonasi is commonly used to induce ovulation in women with anovulatory infertility, to support the luteal phase in assisted reproductive technology, to treat cryptorchidism in male infants, and to stimulate testosterone production in men with hypogonadism.

Gonasi is generally not used in confirmed pregnancy unless specifically indicated by a specialist; pregnancy status should be verified before treatment.

Common side effects include injection‑site pain, headache, nausea, breast tenderness, and mild fluid retention.

Serious reactions can include ovarian hyperstimulation syndrome, allergic reactions such as anaphylaxis, thromboembolic events, ovarian torsion, and rapid weight gain from fluid overload.

Patients with a history of thromboembolic disease should be monitored closely, and the benefits and risks of Gonasi should be evaluated by their healthcare provider.

High‑dose estrogen therapy should be avoided due to an increased risk of ovarian hyperstimulation, and anticoagulants require careful monitoring.

No, Gonasi is a prescription‑only medication (Rx) and must be prescribed by a qualified healthcare professional.

Gonasi binds to luteinizing hormone (LH) receptors, mimicking LH activity, which stimulates ovulation in women and supports testosterone production in men.

Regular ultrasound monitoring of ovarian size, serum hormone levels, and assessment for signs of ovarian hyperstimulation are recommended.

Yes, Gonasi can be used to stimulate endogenous testosterone production in men with hypogonadism, under specialist supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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