Product image of Gonasi Set (Human Chorionic Gonadotropin) supplied by GNH India

Gonasi Set

Active Ingredient:
Human Chorionic Gonadotropin
Origin:
EU

Gonasi Set (Human Chorionic Gonadotropin)

Gonasi Set is a prescription injectable solution that contains the hormone human chorionic gonadotropin (hCG). It is supplied as a sterile liquid for intramuscular or subcutaneous administration and is marketed in the European Union for use in fertility and reproductive endocrinology. The product is classified as a gonadotropin hormone and is intended for professional medical use under a physician’s supervision.

Manufacturer / TM Owner

Ibsa Farmaceutici Italia

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Indications & Clinical Uses

Gonasi Set is employed in several reproductive medicine protocols to support ovulation and luteal function. It is commonly used in assisted reproductive technologies and specific pediatric endocrine conditions.

  • Induction of ovulation in women undergoing intra‑uterine insemination or timed intercourse.
  • Luteal phase support following in vitro fertilisation (IVF) embryo transfer.
  • Treatment of infertility caused by anovulation or luteal insufficiency.
  • Management of cryptorchidism in male infants to stimulate testicular descent.
  • Adjunct therapy in controlled ovarian hyperstimulation cycles.

Side Effects

Side effects of Gonasi Set vary in frequency and severity. Most patients experience mild, transient reactions, while rare serious events may require medical attention.

Common

  • Injection site pain, redness, or swelling.
  • Headache or mild dizziness.
  • Nausea or abdominal discomfort.
  • Temporary flu‑like symptoms such as low‑grade fever.

Serious

  • Ovarian hyperstimulation syndrome (OHSS) presenting with rapid weight gain, abdominal distension, or shortness of breath.
  • Allergic reactions including rash, itching, swelling, or anaphylaxis.

Precautions & Warnings

Before prescribing Gonasi Set, clinicians should evaluate patient history and monitor for potential risks. The following precautions are recommended:

  • Verify absence of pregnancy in women receiving hCG for ovulation induction.
  • Assess for ovarian cysts or prior episodes of OHSS.
  • Use caution in patients with thyroid disorders, as hCG can affect thyroid hormone levels.
  • Monitor blood pressure in individuals with cardiovascular disease.
  • Adjust dose or discontinue if signs of severe OHSS develop.
  • Counsel patients on proper injection technique to reduce local reactions.

Avoid Interactions

Gonasi Set may interact with other medications or hormonal agents, influencing efficacy or safety. Consider the following when co‑administering:

Avoid

  • Concurrent use of high‑dose estrogen preparations that may exacerbate OHSS.
  • Uncontrolled thyroid hormone therapy that could be destabilized by hCG.

Use with caution

  • Gonadotropin‑releasing hormone (GnRH) agonists or antagonists used in IVF protocols.
  • Anticoagulants, as hCG can increase thrombotic risk in susceptible patients.
  • Steroids that may mask early signs of allergic reactions.
  • Diuretics, which could affect fluid balance during OHSS.

Frequently Asked Questions

Gonasi Set contains hCG, which binds to LH/hCG receptors in the ovaries, stimulating steroid hormone production and final maturation of the follicle, thereby triggering ovulation and supporting the luteal phase after embryo transfer.

The medication is injected intramuscularly or subcutaneously, typically as a single dose timed to the patient’s follicular development, under the guidance of a fertility specialist.

Gonasi Set is primarily indicated for female reproductive indications, but hCG is also used off‑label in men to stimulate testosterone production; such use should be directed by a qualified physician.

Patients are usually monitored with serum progesterone levels, ultrasound assessment of the corpus luteum, and observation for signs of ovarian hyperstimulation syndrome throughout the luteal phase.

Because hCG can stimulate thyroid hormone synthesis, clinicians should evaluate thyroid function before treatment and monitor thyroid parameters during therapy, especially in patients with known thyroid disorders.

Symptoms include rapid weight gain, abdominal pain or swelling, shortness of breath, decreased urine output, and severe nausea or vomiting. Prompt evaluation is needed if these occur.

The product should be kept refrigerated between 2 °C and 8 °C (36 °F–46 °F) and protected from light. Do not freeze; discard any solution that appears discolored or contains particles.

Oral contraceptives are generally discontinued before initiating hCG therapy to avoid interference with follicular development; timing should follow the protocol prescribed by the treating physician.

Dosing for cryptorchidism is weight‑based and determined by a pediatric endocrinologist; it is not a fixed adult dose and must be individualized for each infant.

Contraindications include known hypersensitivity to hCG, active pregnancy when used for ovulation induction, uncontrolled thyroid disease, and severe ovarian cysts or previous severe OHSS.

The patient should contact their healthcare provider promptly; the provider will advise whether to administer the missed dose, adjust the treatment schedule, or restart the protocol.

No, Gonasi Set is not classified as a controlled substance; it is a prescription‑only medication regulated under standard pharmaceutical laws.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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