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Gonif

Active Ingredient:
Cefuroxime Sodium
Origin:
EU

Gonif (Cefuroxime Sodium)

Gonif is a prescription injectable solution that contains the active ingredient cefuroxime sodium. It is a second‑generation cephalosporin antibiotic supplied in an unspecified strength for intramuscular or intravenous administration. Marketed in the European Union, Gonif works by inhibiting bacterial cell‑wall synthesis, making it suitable for treating a range of bacterial infections under medical supervision.

Manufacturer / TM Owner

Kleva Pharmaceuticals

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Indications & Clinical Uses

Gonif is indicated for the treatment of several bacterial infections where a broad‑spectrum cephalosporin is appropriate.

  • Respiratory tract infections such as pneumonia and bronchitis
  • Urinary tract infections, including uncomplicated cystitis
  • Skin and soft‑tissue infections like cellulitis
  • Meningitis caused by susceptible organisms
  • Gonorrhea and other sexually transmitted infections
  • Otitis media in pediatric and adult patients

Side Effects

Side effects of Gonif vary in frequency and severity. Patients should be aware of both common and serious reactions.

Common

  • Nausea or vomiting
  • Diarrhea or loose stools
  • Injection site pain or erythema
  • Headache
  • Transient elevation of liver enzymes

Serious

  • Severe allergic reactions (anaphylaxis, Stevens‑Johnson syndrome)
  • Clostridioides difficile‑associated diarrhea
  • Hemolytic anemia
  • Renal impairment or interstitial nephritis

Precautions & Warnings

Before using Gonif, clinicians should consider several safety factors to minimize risk.

  • Assess patient history for penicillin or cephalosporin allergy
  • Use caution in patients with renal dysfunction; dose adjustment may be required
  • Monitor liver function tests during prolonged therapy
  • Evaluate for potential overgrowth of non‑susceptible organisms, especially C. difficile
  • Avoid use in neonates with hyperbilirubinemia due to risk of kernicterus
  • Discuss pregnancy and breastfeeding status with the prescriber, as safety data are limited

Avoid Interactions

Gonif may interact with other medicines, influencing efficacy or safety. Some combinations should be avoided, while others require careful monitoring.

Avoid

  • Concurrent use with other nephrotoxic agents (e.g., aminoglycosides, amphotericin B)
  • Probenecid, which can increase cefuroxime plasma concentrations
  • Warfarin, as cefuroxime may enhance anticoagulant effects

Use with caution

  • Diuretics, due to potential electrolyte disturbances
  • Oral contraceptives, as antibiotics may reduce effectiveness
  • Antacids containing aluminum or magnesium, which may affect absorption when given orally (not applicable to injectable form but noted for completeness)

Frequently Asked Questions

Gonif is used for respiratory tract infections, urinary tract infections, skin and soft‑tissue infections, meningitis, gonorrhea, and otitis media caused by susceptible bacteria.

Gonif is supplied as an injectable solution and can be given either intravenously or intramuscularly by a healthcare professional.

No, Gonif is a prescription‑only medication and must be prescribed by a qualified healthcare provider.

Patients with renal impairment may require dose adjustments, and clinicians should monitor kidney function during treatment.

Common side effects include nausea, diarrhea, injection‑site pain, headache, and temporary increases in liver enzymes.

Serious reactions such as severe allergic responses, Clostridioides difficile‑associated diarrhea, hemolytic anemia, or signs of kidney injury should be reported immediately.

Safety data for Gonif in pregnancy are limited; the medication should only be used if the potential benefit justifies the potential risk to the fetus.

Antibiotics, including cefuroxime, may reduce the effectiveness of hormonal contraceptives, so additional non‑hormonal birth control methods are recommended.

Co‑administration with other antibiotics is possible but should be guided by susceptibility testing and clinical judgment to avoid antagonism or increased toxicity.

Clinicians may monitor renal and hepatic function, complete blood counts, and watch for signs of allergic reactions or gastrointestinal complications.

Cefuroxime generally has limited activity against MRSA; susceptibility testing is needed to determine effectiveness.

The injectable solution should be stored according to the manufacturer’s instructions, typically in a cool, dry place protected from light, and used before the expiration date.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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