Product image of Granored (Granisetron) supplied by GNH India

Granored

Active Ingredient:
Granisetron
Origin:
EU

Granored (Granisetron)

Granored is a prescription oral medication that contains the selective 5‑HT3 receptor antagonist granisetron. It is marketed in the European Union and is supplied without a specified strength or dosage form in the public data. Granisetron works by blocking serotonin receptors in the central nervous system, which helps to reduce the stimulation of the vomiting centre. Granored is used under medical supervision for nausea and vomiting control.

Manufacturer / TM Owner

Dr. Reddy's Laboratories Romania S.R.L.

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Indications & Clinical Uses

Granored is indicated for the prevention and treatment of nausea and vomiting associated with specific medical procedures.

  • Chemotherapy‑induced nausea and vomiting (CINV)
  • Post‑operative nausea and vomiting (PONV)
  • Nausea related to radiation therapy
  • Antiemetic prophylaxis in patients receiving highly emetogenic chemotherapy

Side Effects

The safety profile of granisetron includes both frequent, mild reactions and rare, more serious events.

Common

  • Headache
  • Constipation
  • Diarrhoea
  • Fatigue
  • Dizziness

Serious

  • Allergic reaction (rash, itching, swelling)
  • Cardiac arrhythmia
  • Severe hypotension

Precautions & Warnings

Before prescribing Granored, clinicians should evaluate patient history and consider several precautionary factors.

  • Assess for known hypersensitivity to granisetron or other 5‑HT3 antagonists
  • Use cautiously in patients with prolonged QT interval or cardiac conduction disorders
  • Monitor electrolytes and cardiac status in patients receiving concurrent cardiotoxic chemotherapy
  • Adjust dose or avoid in severe hepatic impairment
  • Consider pregnancy and lactation status; safety data are limited

Avoid Interactions

Granisetron may interact with other medicines, and certain combinations should be avoided or used with careful monitoring.

Avoid

  • Concurrent use with other 5‑HT3 antagonists (e.g., ondansetron) due to additive effects
  • Co‑administration with drugs that significantly prolong the QT interval

Use with caution

  • Antifungal agents such as ketoconazole that inhibit CYP3A4
  • Certain anti‑emetics like aprepitant that affect metabolism
  • Drugs that alter cardiac conduction (e.g., certain antiarrhythmics)

Frequently Asked Questions

Granored is a prescription oral medication whose active ingredient is granisetron, a selective 5‑HT3 receptor antagonist.

Granored is commonly prescribed to prevent or treat chemotherapy‑induced nausea and vomiting and postoperative nausea and vomiting.

Granisetron blocks serotonin 5‑HT3 receptors in the central nervous system, preventing activation of the vomiting centre and thereby reducing nausea.

Yes, granisetron may be used to manage nausea associated with radiation therapy, although it is primarily indicated for chemotherapy and postoperative settings.

Common side effects include headache, constipation, diarrhoea, fatigue, and dizziness.

Serious reactions, although rare, can include allergic responses such as rash or swelling, cardiac arrhythmias, and severe hypotension.

Patients with prolonged QT interval or other cardiac conduction disorders should use Granored cautiously and be monitored closely.

Granored should be avoided with other 5‑HT3 antagonists and with drugs that significantly prolong the QT interval.

Caution is advised when Granored is taken with CYP3A4 inhibitors such as ketoconazole, anti‑emetics like aprepitant, and antiarrhythmic agents that affect cardiac conduction.

Safety data for granisetron during pregnancy and lactation are limited; clinicians should evaluate the risk‑benefit ratio before prescribing.

Patients with severe hepatic impairment may require dose adjustment or avoidance, and liver function should be monitored during therapy.

Granisetron, the active ingredient in Granored, is classified under ATC code A04AA10.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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