Granpidam (Sildenafil)

Granpidam is indicated for specific medical conditions where enhanced blood flow is beneficial.

• Treatment of erectile dysfunction in adult males.
• Management of pulmonary arterial hypertension to improve exercise capacity.
• Off‑label consideration for certain lower urinary tract symptoms related to benign prostatic hyperplasia under physician supervision.
• Component of a comprehensive treatment plan that includes lifestyle modifications.

Side effects of Granpidam vary in frequency and severity.

Common

• Headache.
• Facial flushing.
• Indigestion or dyspepsia.
• Nasal congestion.
• Visual disturbances such as blurred vision.
• Back pain or muscle aches.

Serious

• Priapism (prolonged erection lasting more than 4 hours).
• Sudden loss of vision.
• Sudden loss of hearing.
• Cardiovascular events such as myocardial infarction or stroke.
• Severe hypotension.

Before using Granpidam, certain precautions should be considered to ensure safe use.

• Do not use if you have a known hypersensitivity to sildenafil or any excipients in the tablet.
• Exercise caution if you have cardiovascular disease, especially unstable angina or recent myocardial infarction.
• Use under medical supervision if you have severe liver or kidney impairment.
• Avoid concomitant use with nitrate medications due to risk of profound hypotension.
• Discuss a history of retinal disorders or non‑arteritic anterior ischemic optic neuropathy with your healthcare provider.
• The safety of Granpidam in pregnant or breastfeeding women has not been established; it should not be used in these populations.

Granpidam can interact with several drugs, affecting its efficacy or safety.

Avoid

• Nitrates (e.g., nitroglycerin, isosorbide dinitrate).
• Recreational nitric oxide donors (e.g., amyl nitrate).
• Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir).

Use with caution

• Alpha‑blockers (e.g., doxazosin, tamsulosin).
• Antihypertensive medications.
• Other PDE5 inhibitors.
• Certain antifungal or antibiotic agents (e.g., erythromycin, clarithromycin) that may require dose adjustment.