Granpidam (Sildenafil)

Granpidam is indicated for specific medical conditions where increased blood flow is beneficial.

• Treatment of erectile dysfunction in adult males.
• Management of pulmonary arterial hypertension to improve exercise capacity.
• Adjunct therapy for certain cases of benign prostatic hyperplasia‑related lower urinary tract symptoms (off‑label use in some regions).
• Use in clinical studies evaluating vascular endothelial function.
• Support of right‑ventricular function in patients with chronic heart failure (investigational).
• Potential benefit in high‑altitude pulmonary edema under specialist guidance.

Side effects reported with sildenafil‑containing products vary in frequency and severity.

Common

• Headache.
• Flushing.
• Nasal congestion.
• Dyspepsia or upset stomach.
• Visual disturbances such as blurred vision or a blue tint.
• Muscle aches or back pain.

Serious

• Sudden loss of vision (non‑arteritic anterior ischemic optic neuropathy).
• Sudden hearing loss or ringing in the ears.
• Priapism (prolonged erection lasting more than 4 hours).
• Severe allergic reactions including rash, swelling, or difficulty breathing.

Before starting Granpidam, certain health considerations should be reviewed with a healthcare professional.

• Cardiovascular disease, especially recent myocardial infarction or unstable angina, may increase risk.
• Concomitant use of nitrates or nitric oxide donors is contraindicated due to severe hypotension.
• Patients with severe liver or kidney impairment may require dose adjustment or monitoring.
• History of retinal disorders, such as retinitis pigmentosa, should be disclosed.
• Use is not recommended in individuals with known hypersensitivity to sildenafil or any tablet excipients.
• Caution is advised in patients taking alpha‑blockers for prostate enlargement or hypertension.

Granpidam can interact with other medicines, affecting its safety or effectiveness.

Avoid

• Nitrates (e.g., nitroglycerin, isosorbide dinitrate) – risk of dangerous blood pressure drop.
• Recreational drugs containing poppers (amyl nitrite) – may cause severe hypotension.
• Certain antifungal agents (ketoconazole, itraconazole) – increase sildenafil plasma levels.
• Some antibiotics (e.g., clarithromycin, erythromycin) – may elevate drug concentrations.

Use with caution

• Alpha‑blockers (e.g., tamsulosin, doxazosin) – monitor for additive blood pressure effects.
• Antihypertensive medications – adjust dose if excessive hypotension occurs.
• Protease inhibitors used in HIV therapy – may require dose reduction.
• Diuretics – watch for dehydration and blood pressure changes.