Granpidam (Sildenafil)

Granpidam is indicated for several clinical conditions where vasodilation improves symptoms. It is prescribed by qualified healthcare professionals based on individual assessment.

• Treatment of erectile dysfunction in adult males.
• Management of pulmonary arterial hypertension to improve exercise capacity.
• Adjunct therapy for certain cases of secondary hypertension when other treatments are insufficient.
• Off‑label use may be considered for Raynaud's phenomenon under specialist guidance.
• May be used in clinical trials evaluating vascular function.

Side effects of Granpidam vary in frequency and severity. Patients should be aware of both common and less frequent reactions.

Common

• Headache
• Flushing or warmth sensation
• Indigestion or dyspepsia
• Nasal congestion
• Visual disturbances such as blurred vision

Serious

• Sudden loss of vision (non‑arteritic anterior ischemic optic neuropathy)
• Prolonged erection lasting more than 4 hours (priapism)
• Severe hypotension, especially when combined with nitrates
• Cardiovascular events like myocardial infarction in high‑risk patients
• Allergic reactions including rash, itching, or swelling

Before starting Granpidam, certain health considerations should be reviewed with a healthcare provider.

• Assess cardiovascular status, especially recent heart attack or stroke.
• Evaluate for concurrent use of nitrates or nitric oxide donors.
• Review history of retinal disorders or severe visual impairment.
• Consider renal or hepatic impairment, which may affect drug clearance.
• Discuss any prior episodes of priapism or prolonged erections.
• Inform the prescriber of all current medications, including over‑the‑counter products.

Granpidam can interact with other medicines, influencing its safety and effectiveness.

Avoid

• Nitrates (e.g., nitroglycerin, isosorbide dinitrate) due to risk of severe hypotension.
• Guanylate cyclase stimulators (e.g., riociguat) for pulmonary hypertension.
• Certain potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole) that may increase sildenafil levels.

Use with caution

• Alpha‑blockers for prostate enlargement or hypertension.
• Antihypertensive agents, especially when blood pressure is already low.
• Other PDE5 inhibitors; concurrent use is not recommended.
• Grapefruit juice, which can modestly raise drug concentrations.