Grazax (Phleum Pratense (225))

Grazax is indicated for the treatment of allergic rhinitis caused by grass pollen. Clinical use focuses on long‑term reduction of symptoms and medication need.

• Reduces seasonal nasal congestion, sneezing, and itchy eyes associated with grass pollen.
• Decreases reliance on antihistamines and nasal corticosteroids during grass season.
• Suitable for adults and children with a confirmed grass pollen allergy.
• Administered daily throughout the grass pollen season to maintain tolerance.
• May be considered as part of a broader allergy management plan.

Side effects of Grazax vary in frequency and severity. Most users experience mild, transient reactions, while rare serious events require medical attention.

Common

• Oral itching or mild throat irritation.
• Ear or nasal itching.
• Mild gastrointestinal discomfort.
• Transient swelling of the lips or tongue.
• Localized rash at the site of tablet placement.

Serious

• Anaphylaxis or severe systemic allergic reaction.
• Persistent swelling of the throat that interferes with breathing.
• Severe urticaria (hives) covering large body areas.
• Acute bronchospasm or wheezing.
• Rapid onset of cardiovascular symptoms such as hypotension.

Before starting Grazax, certain precautions should be considered to ensure safe use.

• Confirm diagnosis of grass pollen allergy through skin testing or specific IgE measurement.
• Avoid use in individuals with uncontrolled asthma or recent asthma exacerbations.
• Do not initiate therapy in patients who have experienced anaphylaxis to grass pollen extracts.
• Monitor for local oral reactions during the first weeks of treatment.
• Discuss any history of cardiovascular disease with a healthcare professional.
• Pregnant or breastfeeding individuals should consult a physician before use.

Grazax may interact with other medications or substances that affect the immune system or allergic response.

Avoid

• Concurrent use of other sublingual or subcutaneous grass pollen immunotherapy products.
• Administration of systemic antihistamines or corticosteroids immediately before the tablet, as they may mask early reactions.

Use with caution

• Beta‑blockers, which can interfere with treatment of anaphylaxis.
• ACE inhibitors, due to potential for increased angioedema risk.
• Immunosuppressive agents that may alter the intended immune response.
• Herbal supplements that have known allergenic potential.