Grazax (Phleum Pratense (225))

Grazax is indicated for the prevention of symptoms associated with grass pollen‑induced allergic rhinoconjunctivitis. It is used as a disease‑modifying therapy that aims to reduce the need for symptomatic medications over time.

• Initiated before the start of the grass pollen season.
• Administered daily as a sublingual tablet.
• Intended for patients with confirmed grass pollen allergy.
• May be continued for several years to achieve long‑term tolerance.
• Used under medical supervision with periodic follow‑up.
• Not a rescue medication for acute allergy attacks.

Side effects of Grazax are generally mild to moderate and reflect local or systemic immune responses to the allergen exposure.

Common

• Oral itching or mild irritation at the site of administration.
• Throat irritation or mild soreness.
• Transient ear or nasal itching.
• Mild gastrointestinal discomfort.
• Headache.
• Localized swelling of the lips or tongue.

Serious

• Severe oral or throat swelling that may affect breathing.
• Anaphylactic reaction requiring emergency care.
• Persistent wheezing or shortness of breath.
• Rapid onset of hives or widespread rash.

Patients should consider several precautions before starting Grazax therapy. The medication is not suitable for everyone and requires careful monitoring.

• Confirmed diagnosis of grass pollen allergy by a qualified clinician.
• Not recommended for individuals with uncontrolled asthma.
• Use with caution in patients with a history of severe allergic reactions.
• Avoid initiating treatment during an active allergic episode.
• Pregnant or breastfeeding women should discuss potential risks with their healthcare provider.
• Keep the tablet out of reach of children; accidental ingestion can cause serious reactions.
• Ensure regular follow‑up appointments to assess tolerance development.

Grazax may interact with other medications or substances that affect the immune system or increase the risk of allergic reactions.

Avoid

• Systemic antihistamines taken within 24 hours before the first dose, as they may mask early reactions.
• Immunosuppressive drugs that could alter the intended immune response.
• ACE inhibitors that may exacerbate angioedema.

Use with caution

• Beta‑blockers, which can make treatment of anaphylaxis more difficult.
• Other allergen immunotherapy products administered concurrently.
• Medications that cause dry mouth, potentially affecting tablet dissolution.
• Over‑the‑counter cold or flu remedies that contain antihistamines.