Grazax (Phleum Pratense (225))

Grazax is indicated for patients with grass‑pollen‑related seasonal allergic rhinitis and allergic rhinoconjunctivitis, typically when symptoms are not adequately controlled by standard pharmacotherapy.

• Pre‑seasonal treatment to reduce the severity of grass‑pollen allergy symptoms.
• Adjunct therapy for patients who experience nasal congestion, sneezing, and itchy eyes during the grass pollen season.
• Long‑term immunotherapy aimed at modifying the underlying allergic response.
• Use in adults and adolescents with a confirmed diagnosis of grass pollen allergy.
• May be considered for patients seeking an alternative to daily antihistamines during peak pollen periods.

The safety profile of Grazax includes both frequently observed and less common reactions; most side effects are mild and transient.

Common

• Mild oral itching or tingling at the site of tablet placement.
• Transient sore throat or throat irritation.
• Nasal itching or mild rhinorrhea.
• Mild gastrointestinal discomfort such as nausea.
• Mouth swelling or mild lip edema.

Serious

• Severe allergic reactions, including anaphylaxis, requiring immediate medical attention.
• Persistent or worsening asthma symptoms in patients with underlying asthma.
• Swelling of the face, lips, or tongue indicating a systemic reaction.
• Persistent severe respiratory distress or bronchospasm.

Before initiating Grazax, clinicians should evaluate patient history and consider specific precautions to ensure safe administration.

• Confirm a diagnosis of grass pollen allergy through appropriate testing.
• Avoid use in individuals with uncontrolled or severe asthma.
• Do not administer to patients with a history of severe systemic allergic reactions to allergen immunotherapy.
• Pregnancy and lactation status should be assessed, as safety data are limited.
• Patients should be observed for at least 30 minutes after the first dose for potential reactions.
• Discontinue treatment if serious adverse events occur and seek medical evaluation.

Grazax may interact with other medications or conditions that affect immune response or increase the risk of allergic reactions.

Avoid

• Concurrent use of beta‑blockers, which can diminish the effectiveness of emergency epinephrine treatment.
• Other allergen immunotherapy products targeting the same allergen, to prevent overlapping exposure.

Use with caution

• Antihistamines or corticosteroids, as they may mask early signs of an allergic reaction.
• ACE inhibitors, which have been associated with increased incidence of angio‑edema.
• Biologic agents that modulate immune function, such as omalizumab.
• Vaccinations, especially live vaccines, should be timed appropriately around immunotherapy.