Gripalgin (Chlorphenamine Maleate, Phenylephrine Bitartrate, Paracetamol)

Gripalgin is indicated for the symptomatic treatment of upper respiratory infections such as the common cold and influenza.

• Relief of nasal congestion caused by swollen nasal passages.
• Reduction of headache, fever, and sore throat associated with viral infections.
• Alleviation of watery eyes, runny nose, and sneezing due to allergic components of cold.
• Temporary easing of body aches and mild pain that accompany flu-like illness.
• Support for improved comfort during rest and daily activities when experiencing cold symptoms.
• Assistance in maintaining normal sleep patterns disrupted by congestion and discomfort.

The combination of chlorphenamine, phenylephrine and paracetamol may produce a range of adverse effects. Most are mild, dose‑related, and resolve without medical intervention, but patients should be aware of the typical profile.

Common

• Drowsiness, mild sedation, or feeling of fatigue.
• Dryness of the mouth, throat, or nasal mucosa.
• Nausea, mild stomach upset, or transient loss of appetite.
• Light‑headedness or a brief increase in heart rate.
• Mild headache or dizziness that improves with rest.

Serious

• Severe allergic reaction such as rash, itching, swelling of the face or throat, or difficulty breathing (anaphylaxis).
• Marked increase in blood pressure, chest pain, or signs of cardiovascular strain.
• Liver dysfunction indicated by jaundice, dark urine, or persistent abdominal pain.

When using Gripalgin, certain precautions should be observed to minimize risk and ensure safe use.

• Do not exceed the recommended dose; overdose increases risk of liver injury from paracetamol.
• Use caution if you have hypertension, heart disease, diabetes, or thyroid disorders, as phenylephrine may raise blood pressure.
• Avoid if you are hypersensitive to any ingredient.
• Consult a healthcare professional before use during pregnancy, breastfeeding, or in children.
• Limit alcohol while taking this medication, as it may increase liver toxicity.
• Chlorphenamine can cause drowsiness; avoid driving or operating machinery until you know how you react.

Gripalgin may interact with other medicines; recognizing potential interactions helps maintain safety.

Avoid

• Concurrent use with other products containing paracetamol or acetaminophen, which can lead to excessive dosing and liver damage.
• Combining with monoamine oxidase inhibitors (MAOIs) or other sympathomimetic agents, which may cause excessive cardiovascular stimulation.

Use with caution

• Other antihistamines or sedatives, as additive drowsiness may occur.
• Anticoagulants or antiplatelet drugs, because paracetamol can modestly affect bleeding risk.
• Certain antidepressants (e.g., SSRIs) or tramadol, which may increase the risk of serotonin syndrome when combined with phenylephrine.
• Patients taking diuretics should monitor electrolyte balance, as phenylephrine may affect potassium levels.