Gripex (Dextromethorphan Hydrobromide, Pseudoephedrine Hydrochloride, Paracetamol)

Gripex is indicated for the symptomatic treatment of common cold and influenza, providing multi‑symptom relief in adults seeking over‑the‑counter options.

• Relief of cough associated with upper respiratory infections.
• Temporary reduction of nasal congestion caused by swollen nasal passages.
• Alleviation of mild to moderate pain such as headache, sore throat, or muscle aches.
• Reduction of fever and discomfort through antipyretic action.
• Support for overall comfort during cold or flu episodes.
• Assistance in maintaining normal daily activities by easing multiple cold symptoms simultaneously.

Like many combination cold remedies, Gripex may cause side effects that vary in frequency and severity.

Common

• Drowsiness or mild sedation.
• Dry mouth or throat irritation.
• Nausea, upset stomach, or loss of appetite.
• Nasal dryness or mild headache.
• Light‑headedness or dizziness.
• Mild insomnia or difficulty sleeping.
• Increased sweating.
• Slight tremor.
• Blurred vision.

Serious

• Allergic reactions such as rash, itching, swelling, or difficulty breathing.
• Elevated blood pressure or rapid heart rate, especially in individuals sensitive to pseudoephedrine.
• Severe liver injury (rare) indicated by jaundice or dark urine.
• Persistent vomiting or inability to keep fluids down.
• Seizures (very rare) especially with high doses.
• Hallucinations or confusion (rare).

When using Gripex, certain precautions should be observed to minimize risks and ensure safe use.

• Do not exceed the recommended daily dose; higher amounts increase risk of side effects.
• Avoid use in individuals with uncontrolled hypertension, severe heart disease, or hyperthyroidism.
• Consult a healthcare professional before taking Gripex if you are pregnant, breastfeeding, or have liver or kidney impairment.
• Keep the product out of reach of children; accidental ingestion can be hazardous.
• Do not combine with other products containing paracetamol, dextromethorphan, or pseudoephedrine to prevent overdose.
• Limit alcohol consumption while using this medication, as it may enhance drowsiness.

Gripex can interact with other medicines, which may require avoidance or careful monitoring.

Avoid

• Monoamine oxidase inhibitors (MAOIs) or other serotonergic agents, due to risk of serotonin syndrome with dextromethorphan.
• Other decongestants containing pseudoephedrine or phenylephrine, which can raise blood pressure excessively.
• Additional paracetamol‑containing products, to prevent hepatotoxic overdose.
• Certain antidepressants (e.g., SSRIs, SNRIs) because of additive serotonergic effects.

Use with caution

• Antihypertensive drugs, as pseudoephedrine may counteract blood‑pressure‑lowering effects.
• Anticoagulants such as warfarin, because paracetamol can enhance anticoagulant activity.
• Central nervous system depressants (e.g., benzodiazepines, alcohol), which may increase drowsiness when combined with dextromethorphan.
• Antihistamines that cause drowsiness, as combined sedation may be enhanced.
• Antihypertensive drugs, as pseudoephedrine may counteract blood‑pressure‑lowering effects.