Gripex (Dextromethorphan Hydrobromide, Pseudoephedrine Hydrochloride, Paracetamol)

Gripex is indicated for the temporary relief of several common cold and flu symptoms. It is used when patients experience a combination of cough, nasal congestion, and mild to moderate pain or fever.

• Suppression of non‑productive cough associated with upper respiratory infections.
• Reduction of nasal congestion caused by inflamed nasal passages.
• Relief of headache, sore throat, or body aches linked to viral illnesses.
• Lowering of fever and discomfort during a cold or flu episode.
• Supportive care for general cold symptoms when multiple complaints coexist.

Side effects of Gripex may vary in frequency and severity. Most are mild and transient, but some require medical attention.

Common

• Dry mouth or throat irritation.
• Mild dizziness or light‑headedness.
• Nausea or mild stomach upset.
• Temporary insomnia or difficulty sleeping.
• Mild headache.
• Increased heart rate or mild palpitations.

Serious

• Severe allergic reaction (rash, itching, swelling, difficulty breathing).
• High blood pressure spikes.
• Persistent or worsening cough.
• Hallucinations or confusion (rare with dextromethorphan overdose).

Before using Gripex, consider the following precautions to ensure safe use. These points help identify situations where additional monitoring or alternative therapy may be needed.

• Consult a healthcare professional if you have hypertension, heart disease, diabetes, or thyroid disorders.
• Avoid use in individuals taking monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping them.
• Use caution if you are pregnant, planning to become pregnant, or breastfeeding; discuss risks with a clinician.
• Do not exceed the recommended daily dose; overuse can increase risk of liver injury from paracetamol.
• Keep out of reach of children; accidental ingestion can be dangerous.
• Monitor for signs of allergic reaction, especially if you have known drug sensitivities.

Gripex can interact with other medicines, affecting its safety or effectiveness. Some combinations should be avoided, while others may require dose adjustments or close monitoring.

Avoid

• Monoamine oxidase inhibitors (MAOIs) and other serotonergic agents (risk of serotonin syndrome).
• Other products containing decongestants, such as phenylephrine, which may raise blood pressure.
• Additional paracetamol‑containing products (risk of liver toxicity).
• Certain antidepressants (e.g., SSRIs, SNRIs) that may increase serotonergic activity.

Use with caution

• Antihypertensive drugs (pseudoephedrine may reduce their effect).
• Anticoagulants or antiplatelet agents (paracetamol can affect bleeding risk).
• Alcohol or other central nervous system depressants (may enhance drowsiness).