Product image of Gutron (Midodrine Hydrochloride) supplied by GNH India

Gutron

Active Ingredient:
Midodrine Hydrochloride
Origin:
EU

Gutron (Midodrine Hydrochloride)

Gutron is a tablet that contains the active ingredient Midodrine Hydrochloride. It is marketed in the European Union as a medication and is classified as an alpha‑1 adrenergic agonist vasopressor. The tablet is formulated to be taken by mouth and works as a prodrug that is converted to desglymidodrine, which raises blood pressure by stimulating peripheral alpha‑1 receptors. It is supplied without a milligram strength, allowing clinicians to tailor dosing.

Manufacturer / TM Owner

Cheplapharm Arzneimittel Gmbh

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Indications & Clinical Uses

Gutron (midodrine hydrochloride) is indicated for the management of certain forms of low blood pressure that occur upon standing.

  • Orthostatic hypotension (postural drop in blood pressure)
  • Neurogenic orthostatic hypotension associated with autonomic failure
  • Symptomatic treatment of chronic hypotension when non‑pharmacologic measures are insufficient
  • Adjunct therapy in patients with autonomic nervous system disorders
  • Short‑term support of blood pressure under physician supervision

Side Effects

The safety profile of Gutron reflects the pharmacologic activity of midodrine and includes both frequent, mild reactions and less common, potentially serious events.

Common

  • Tingling or prickling sensations (paresthesia) in the scalp or limbs
  • Increased urinary frequency or urgency
  • Mild supine hypertension
  • Headache

Serious

  • Severe supine hypertension
  • Chest pain or angina
  • Peripheral edema

Precautions & Warnings

Clinicians should evaluate patient history and monitor specific conditions before prescribing Gutron because the drug can affect blood pressure and cardiovascular function.

  • Avoid use in patients with severe organic heart disease
  • Exercise caution in patients with renal or hepatic impairment
  • Monitor supine blood pressure regularly during therapy
  • Do not combine with other vasoconstrictors without supervision
  • Use with caution in individuals prone to urinary retention
  • Avoid in pregnancy unless the potential benefit justifies the risk
  • Educate patients to remain upright for at least 3 hours after each dose

Avoid Interactions

Midodrine may interact with several medications that influence blood pressure, vascular tone, or renal clearance.

Avoid

  • Other vasopressors or alpha‑1 agonists
  • Monoamine oxidase inhibitors (MAOIs)
  • Tricyclic antidepressants

Use with caution

  • Diuretics
  • Antihypertensive agents
  • Drugs that may increase urinary retention (e.g., anticholinergics)

Frequently Asked Questions

Gutron is primarily prescribed to treat orthostatic hypotension, including neurogenic orthostatic hypotension, by raising standing blood pressure.

Midodrine is a prodrug that is converted to desglymidodrine, which stimulates peripheral alpha‑1 adrenergic receptors, causing vasoconstriction and an increase in blood pressure.

No. Gutron is a prescription‑only medication in the European Union and must be prescribed by a qualified healthcare professional.

Midodrine can interact with other antihypertensive agents; such combinations should be used with caution and under close medical supervision.

Common side effects include scalp or limb tingling, increased urinary frequency, mild supine hypertension, and headache.

Severe supine hypertension, chest pain or angina, and significant peripheral edema are considered serious and require prompt evaluation.

Patients are advised to remain upright for at least three hours after each dose to reduce the risk of supine hypertension.

The pregnancy safety category for Midodrine Hydrochloride is unknown; it should only be used if the potential benefit outweighs any possible risk to the fetus.

After oral administration, Gutron is absorbed and rapidly converted by hepatic enzymes to its active metabolite, desglymidodrine, which exerts the vasopressor effect.

Regular monitoring of supine and standing blood pressure, assessment for signs of urinary retention, and periodic evaluation of renal and hepatic function are recommended.

Yes, Gutron is indicated for neurogenic orthostatic hypotension, which often occurs in autonomic failure, but dosing should be individualized.

If a dose is missed, the patient should take it as soon as remembered unless it is close to the time of the next scheduled dose; they should not double the dose.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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