Gyno-Pevaryl Once (Econazole Nitrate)

Gyno-Pevaryl Once is indicated for the treatment of vulvovaginal candidiasis, a common yeast infection caused by Candida species.

• Eradicates Candida overgrowth in the vaginal canal.
• Relieves symptoms such as itching, burning, and abnormal discharge.
• Used as a single‑application therapy for uncomplicated infections.
• May be employed after confirming diagnosis of fungal origin.
• Provides local antifungal activity without systemic absorption.

Side effects associated with vaginal econazole nitrate are generally mild, but some users may experience more pronounced reactions.

Common

• Local irritation or burning sensation.
• Vaginal itching or redness.
• Mild discharge with a whitish or yellowish tint.
• Unpleasant odor at the application site.

Serious

• Severe allergic reaction such as rash, swelling, or difficulty breathing.
• Persistent or worsening vaginal symptoms despite treatment.
• Signs of secondary bacterial infection (e.g., fever, foul odor).

Before using Gyno-Pevaryl Once, consider the following precautions to ensure safe and effective treatment.

• Confirm diagnosis of fungal infection; avoid use for bacterial or viral vaginitis.
• Do not use if you are allergic to econazole or other imidazole antifungals.
• Avoid application during menstruation or if the vaginal mucosa is severely inflamed.
• Consult a healthcare professional if pregnant, planning pregnancy, or breastfeeding.
• Keep the applicator sealed until use and store at room temperature away from moisture.
• Discontinue use and seek medical advice if symptoms persist beyond the expected treatment period.

Econazole nitrate may interact with other substances applied vaginally or taken systemically; be aware of the following.

Avoid

• Concurrent use of other intravaginal antifungal or antiseptic products, which may reduce efficacy.
• Use with spermicidal agents that can irritate the mucosa.

Use with caution

• Systemic azole antifungals (e.g., fluconazole) as combined therapy may increase local irritation.
• Hormonal contraceptives delivered vaginally, as absorption could be altered.
• Herbal or over‑the‑counter vaginal products, which might cause additive irritation.