Gynoflor (Estriol, Lactobacillus Acidophilus, Lyophilized)

Gynoflor is prescribed for several post‑menopausal and estrogen‑deficient conditions affecting the vagina. It is used to improve the health of the vaginal epithelium and restore a normal microbiota.

• Treatment of vaginal atrophy caused by estrogen deficiency
• Relief of dyspareunia associated with genital dryness
• Management of vaginal dryness and irritation
• Support of vaginal flora after antibiotic therapy
• Adjunct therapy for mild genitourinary syndrome of menopause

Side effects of Gynoflor are generally mild and related to local vaginal exposure. Serious adverse events are uncommon but should be reported to a healthcare professional.

Common

• Vaginal discharge or spotting
• Mild irritation or burning sensation
• Local itching or discomfort
• Transient increase in vaginal secretions
• Mild abdominal cramping

Serious

• Allergic reaction (rash, swelling, difficulty breathing)
• Severe vaginal irritation or ulceration
• Unexplained vaginal bleeding
• Signs of infection (fever, foul odor)
• Persistent pelvic pain

Before using Gynoflor, certain precautions should be considered to ensure safe and effective therapy.

• Confirm that the patient is not pregnant; safety in pregnancy is not established.
• Use only under medical supervision; it is a prescription‑only product.
• Assess for a history of estrogen‑dependent neoplasia or thromboembolic disorders.
• Monitor for signs of vaginal infection or abnormal bleeding.
• Advise patients to report any severe local reactions promptly.
• Store tablets in a dry place, protected from moisture and heat.

Gynoflor may interact with other medications or substances that affect estrogen pathways or vaginal health.

Avoid

• Concurrent use of systemic estrogen therapy without medical guidance.
• Use with potent vaginal irritants (e.g., douches, antiseptic washes).
• Simultaneous administration of antifungal agents that may alter probiotic viability.

Use with caution

• Hormonal contraceptives containing estrogen.
• Anticoagulants, if systemic absorption is suspected.
• Medications that influence vaginal pH (e.g., certain antibiotics).
• Herbal supplements with estrogenic activity.