Product image of Gynofort (Butoconazole Nitrate) supplied by GNH India

Gynofort

Active Ingredient:
Butoconazole Nitrate
Origin:
EU

Gynofort (Butoconazole Nitrate)

Gynofort is a prescription vaginal tablet that contains 2 mg of butoconazole nitrate, an imidazole‑type antifungal agent. The medication is formulated for vaginal use and is marketed in the European Union for the treatment of fungal infections of the vulva and vagina. It belongs to the therapeutic class of antifungals and works by disrupting fungal cell membrane synthesis. Butoconazole nitrate interferes with ergosterol production, a key component of fungal cell membranes, leading to inhibited growth.

Manufacturer / TM Owner

Gedeon Richter Plc.

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Indications & Clinical Uses

Gynofort is indicated for the treatment of vulvovaginal candidiasis, a common yeast infection affecting the female genital tract. It is used when a short course of local antifungal therapy is required.

  • Treatment of acute vulvovaginal candidiasis caused by Candida species.
  • Management of recurrent yeast infections when prescribed by a healthcare professional.
  • Adjunct therapy for mixed bacterial‑fungal vaginal infections, as directed.
  • Use in women who prefer a single‑dose intravaginal tablet regimen.
  • Therapeutic option for patients who cannot tolerate oral antifungal agents.

Side Effects

The safety profile of Gynofort reflects the typical reactions observed with topical imidazole antifungals. Most side effects are mild and transient, while rare events may require medical attention.

Common

  • Mild vaginal irritation or burning sensation.
  • Transient itching or discomfort at the application site.
  • Light vaginal discharge with a slight odor.

Serious

  • Severe allergic reaction such as rash, hives, or swelling.
  • Persistent or worsening vaginal pain or ulceration.
  • Signs of systemic infection like fever or chills.

Precautions & Warnings

Before using Gynofort, certain conditions and patient factors should be considered to ensure safe and effective therapy.

  • Confirm diagnosis of candidiasis before initiating treatment.
  • Do not use if there is known hypersensitivity to butoconazole or other imidazoles.
  • Avoid use during active vaginal bleeding or trauma.
  • Consult a healthcare provider if pregnant or planning pregnancy.
  • Use only as prescribed; do not exceed the recommended dose.
  • Report any persistent irritation or unexpected symptoms promptly.

Avoid Interactions

Butoconazole nitrate may interact with other medications applied intravaginally or systemic agents that affect fungal flora.

Avoid

  • Concurrent use of other vaginal antifungal or spermicidal products.
  • Combination with systemic azole antifungals without medical supervision.
  • Use with vaginal douches or antiseptic washes during therapy.

Use with caution

  • Topical corticosteroids applied to the vagina, which may mask irritation.
  • Hormonal contraceptives that alter vaginal pH.
  • Systemic immunosuppressants that increase risk of fungal overgrowth.

Frequently Asked Questions

Gynofort contains butoconazole nitrate, an imidazole antifungal that inhibits the fungal enzyme lanosterol 14α-demethylase, blocking ergosterol synthesis and disrupting the cell membrane of Candida species.

Gynofort is inserted as a single vaginal tablet into the vagina, usually at bedtime, following the instructions provided by a healthcare professional.

The pregnancy category for butoconazole nitrate is listed as unknown. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their clinician before using Gynofort.

Common side effects include mild vaginal irritation, burning, itching, and a light discharge with a slight odor. These effects are usually temporary and resolve without medical intervention.

If you experience severe allergic reactions such as rash, hives, swelling, persistent pain, ulceration, or signs of systemic infection like fever or chills, you should contact a healthcare provider promptly.

Concurrent use of other vaginal antifungal or spermicidal products, as well as vaginal douches or antiseptic washes, should be avoided unless directed by a clinician.

Yes, Gynofort may be prescribed for recurrent vulvovaginal candidiasis when a short‑course intravaginal therapy is appropriate, but the underlying cause should be evaluated by a healthcare professional.

Gynofort is typically administered as a single dose. If the tablet is not inserted as instructed, contact your prescriber for guidance rather than taking an additional dose.

Combining Gynofort with systemic azole antifungals should only be done under medical supervision, as overlapping antifungal activity may increase the risk of adverse effects.

Many women notice a reduction in itching and discharge within a few days, but complete resolution of infection may take up to a week. Continue to follow up with your clinician if symptoms persist.

Butoconazole nitrate itself does not contain latex, but the applicator may. If you have a known latex allergy, discuss alternative insertion methods with your healthcare provider.

Avoid using vaginal douches, antiseptic washes, or other intravaginal medications unless prescribed, and refrain from sexual intercourse if it causes discomfort until symptoms improve.

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GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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