Hadmuliv (Ibuprofen, Paracetamol)

Hadmuliv is indicated for the temporary relief of several common conditions that involve pain or elevated temperature.

• Mild to moderate musculoskeletal pain, such as backache or sprains.
• Tension‑type headache and other primary headache disorders.
• Fever associated with viral or bacterial infections.
• Dental pain following procedures or toothache.
• Post‑vaccination discomfort and low‑grade fever.
• Menstrual cramps when additional analgesia is required.

The safety profile of Hadmuliv reflects the combined effects of ibuprofen and paracetamol, with most reactions being mild and reversible.

Common

• Nausea or mild stomach upset.
• Indigestion or heartburn.
• Transient headache.
• Dizziness or light‑headedness.
• Mild skin rash or itching.

Serious

• Gastrointestinal bleeding or ulcer perforation.
• Elevated liver enzymes or hepatic injury.
• Severe allergic reactions such as anaphylaxis.
• Acute kidney injury, especially with dehydration.
• Blood disorders like thrombocytopenia (rare).

Before using Hadmuliv, certain health considerations should be reviewed to minimize risk.

• Known hypersensitivity to ibuprofen, paracetamol, or other NSAIDs.
• History of peptic ulcer disease or gastrointestinal bleeding.
• Severe liver disease or markedly elevated liver enzymes.
• Impaired renal function, chronic dehydration, or use of diuretics.
• Pregnancy, particularly the third trimester, unless advised by a clinician.
• Concurrent use of other NSAIDs or high‑dose paracetamol products.
• Chronic alcohol consumption that may increase liver toxicity.

Hadmuliv can affect the activity of other medicines; some combinations should be avoided while others require careful monitoring.

Avoid

• Other NSAIDs (e.g., aspirin, diclofenac) due to additive gastrointestinal risk.
• Additional paracetamol‑containing products to prevent overdose.

Use with caution

• Anticoagulants such as warfarin, because ibuprofen may increase bleeding risk.
• Antihypertensive agents (ACE inhibitors, diuretics, beta‑blockers) as NSAIDs can reduce their efficacy.
• Lithium or methotrexate, where ibuprofen may raise serum concentrations.
• Certain antidiabetic drugs, as NSAIDs can affect blood glucose control.
• SSRIs or other serotonergic agents, which may increase bleeding tendency.